手机射频电磁辐射与脑肿瘤之间的关系:使用各种射频电磁辐射暴露代用指标进行荟萃分析--结果评估。

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Pub Date : 2024-10-10 DOI:10.1186/s12940-024-01117-8
Jinyoung Moon, Jungmin Kwon, Yongseok Mun
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引用次数: 0

摘要

简介作者通过应用各种射频电磁辐射(RF-EMR)暴露子类别,对手机和移动电话的使用与脑肿瘤发展之间的关系进行了荟萃分析。随着移动电话使用模式的变化和无线个人局域网(WPAN)技术(如蓝牙)的快速发展,本研究将深入探讨更精确的射频电磁辐射暴露子类别的重要性:医学图书管理员检索了 MEDLINE (PubMed)、EMBASE 和 Cochrane 图书馆,直至 2020 年 12 月 16 日:在这些荟萃分析中,共纳入了 19 项病例对照研究和 5 项队列研究。与非定期使用者相比,双侧使用者的合并几率比(OR)为 1.40(95% CI 1.21-1.62)。使用年限超过 10 年的使用者报告的集合 OR 为 1.27(95% CI 1.08-1.48)。按脑肿瘤类型进行分层时,只有脑膜瘤(OR 1.20 (95% CI 1.04-1.39))、胶质瘤(OR 1.45 (95% CI 1.16-1.82))和恶性脑肿瘤(OR 1.93 (95% CI 1.55-2.39))的同侧使用者的OR值增加,且具有统计学意义。对于使用年限超过 10 年的使用者,只有胶质瘤(OR 1.32 (95% CI 1.01-1.71))的 OR 值增加,且具有统计学意义。如果对累计使用时间超过 896 小时且 OR 值为 1.59(95% CI 1.25-2.02)的 11 项研究进行综合,则汇总 OR 值为 1.59(95% CI 1.25-2.02)。当按脑肿瘤类型进行分层时,胶质瘤、脑膜瘤和听神经瘤的集合 OR 分别为 1.66(95% CI 1.13-2.44)、1.29(95% CI 1.08-1.54)和 1.84(95% CI 0.78-4.37)。在考虑累积使用时间的各项研究中,胶质瘤、脑膜瘤和听神经瘤的最高OR值分别为2.89(1.41-5.93)(双侧使用,>896小时)、2.57(1.02-6.44)(双侧使用,>896小时)和3.53(1.59-7.82)(同侧使用,>1640小时)。在五项队列研究中,所有中枢神经系统肿瘤、胶质瘤、脑膜瘤和听神经瘤的汇总风险比(RRs)在统计学上分别是等效的。然而,听神经瘤的点估计值显示,与从未使用相比,曾经使用(1.26)和使用 10 年以上(1.61)的风险比分别增加了:在这项荟萃分析中,随着所使用的暴露子类别变得更加具体,集合 ORs 显示出更高的数值,并具有统计学意义。虽然对队列研究的荟萃分析得出的集合效应估计值在统计学上没有定论,但(i) 随着纳入研究的数量增加,(ii) 随着所使用的暴露亚类变得更加具体,集合 RRs 在未来的研究中可能会显示出不同的方面。此外,未来的研究应充分考虑移动电话使用模式的变化以及越来越多地使用带有 WPAN 技术的耳机或耳机。
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Relationship between radiofrequency-electromagnetic radiation from cellular phones and brain tumor: meta-analyses using various proxies for RF-EMR exposure-outcome assessment.

Introduction: The authors conducted meta-analyses regarding the association between cellular and mobile phone use and brain tumor development by applying various radiofrequency-electromagnetic radiation (RF-EMR) exposure subcategories. With changing patterns of mobile phone use and rapidly developing Wireless Personal Area Network (WPAN) technology (such as Bluetooth), this study will provide insight into the importance of more precise exposure subcategories for RF-EMR.

Methods: The medical librarian searched MEDLINE (PubMed), EMBASE, and the Cochrane Library until 16 December 2020.

Results: In these meta-analyses, 19 case-control studies and five cohort studies were included. Ipsilateral users reported a pooled odds ratio (OR) of 1.40 (95% CI 1.21-1.62) compared to non-regular users. Users with years of use over 10 years reported a pooled OR of 1.27 (95% CI 1.08-1.48). When stratified by each type of brain tumor, only meningioma (OR 1.20 (95% CI 1.04-1.39)), glioma (OR 1.45 (95% CI 1.16-1.82)), and malignant brain tumors (OR 1.93 (95% CI 1.55-2.39)) showed an increased OR with statistical significance for ipsilateral users. For users with years of use over 10 years, only glioma (OR 1.32 (95% CI 1.01-1.71)) showed an increased OR with statistical significance. When 11 studies with an OR with cumulative hours of use over 896 h were synthesized, the pooled OR was 1.59 (95% CI 1.25-2.02). When stratified by each type of brain tumor, glioma, meningioma, and acoustic neuroma reported the pooled OR of 1.66 (95% CI 1.13-2.44), 1.29 (95% CI 1.08-1.54), and 1.84 (95% CI 0.78-4.37), respectively. For each individual study that considered cumulative hours of use, the highest OR for glioma, meningioma, and acoustic neuroma was 2.89 (1.41-5.93) (both side use, > 896 h), 2.57 (1.02-6.44) (both side use, > 896 h), and 3.53 (1.59-7.82) (ipsilateral use, > 1640 h), respectively. For five cohort studies, the pooled risk ratios (RRs) for all CNS tumors, glioma, meningioma, and acoustic neuroma, were statistically equivocal, respectively. However, the point estimates for acoustic neuroma showed a rather increased pooled RR for ever-use (1.26) and over 10 years of use (1.61) compared to never-use, respectively.

Discussion: In this meta-analysis, as the exposure subcategory used became more concrete, the pooled ORs demonstrated higher values with statistical significance. Although the meta-analysis of cohort studies yielded statistically inconclusive pooled effect estimates, (i) as the number of studies included grows and (ii) as the applied exposure subcategories become more concrete, the pooled RRs could show a different aspect in future research. Additionally, future studies should thoroughly account for changing patterns in mobile phone use and the growing use of earphones or headphones with WPAN technology.

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来源期刊
Environmental Health
Environmental Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
10.10
自引率
1.70%
发文量
115
审稿时长
3.0 months
期刊介绍: Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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