母亲在怀孕期间做运动与降低婴儿患哮喘的风险有关:一项前瞻性出生队列研究。

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Med Pub Date : 2024-10-08 DOI:10.1016/j.medj.2024.09.003
Emma-Reetta Musakka, Maija Paula Tuulia Ylilauri, Jonna Jalanka, Anne Maarit Karvonen, Martin Täubel, Sari Hantunen, Soili Marianne Lehto, Juha Pekkanen, Katri Backman, Leea Keski-Nisula, Pirkka Viljami Kirjavainen
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引用次数: 0

摘要

背景:哮喘初级预防的手段有限。孕妇在怀孕期间进行体育锻炼可促进胎儿肺部发育和新生儿肺部功能,从而降低哮喘风险并有助于预防哮喘。本研究的目的是确定孕期母体活动是否与儿童哮喘的发生有关:研究对象包括库奥皮奥出生队列前瞻性研究中的 963 对母婴。从库奥皮奥大学医院的出生登记表和调查问卷中获得了有关母亲孕期体力活动、混杂因素以及儿童5至7岁时哮喘情况的数据:母亲在怀孕期间每周进行三次或三次以上的体育锻炼可降低儿童患哮喘的风险,调整后的几率比为 0.54(95% 置信区间为 0.33-0.89;P = 0.02)。在进行一系列综合调整后,包括妊娠期长短、分娩方式、孕产妇健康指标(如哮喘、吸烟、孕前体重指数和孕期体重增加、感染、药物治疗、健康饮食、压力)以及各种家庭环境变数,这种关联仍保持稳定:结论:孕期母亲的体力活动可能与儿童期哮喘的明显保护有关,应将其作为预防哮喘的一项适用措施进行进一步研究:本研究得到了芬兰科学院(编号:349427)、埃米尔-阿尔托宁基金会(Emil Aaltonen Foundation)、芬兰文化基金会(Finnish Cultural Foundation)、Yrjö Jahnsson基金会、Juho Vainio基金会(编号:202200461)、库奥皮奥地区呼吸基金会(Kuopio Area Respiratory Foundation)和艾达-蒙蒂尼基金会(Ida Montini Foundation)的资助。
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Maternal exercise during pregnancy is associated with reduced risk of asthma in the child: A prospective birth cohort study.

Background: The means of primary prevention of asthma are limited. Maternal physical activity during pregnancy promotes fetal lung development and the newborn's lung function; thus, it could lower asthma risk and aid in asthma prevention. The objective of this study is to determine whether maternal physical activity during pregnancy is associated with asthma development in the child.

Methods: The study population included 963 mother-infant pairs from the prospective Kuopio Birth Cohort study. Data on maternal physical activity during pregnancy, confounding factors, and children's asthma at 5 to 7 years of age were obtained from the Kuopio University Hospital birth registry and questionnaires.

Findings: Maternal physical activity during pregnancy, when practiced three or more times per week, was associated with a reduced risk of asthma in the child, with an adjusted odds ratio of 0.54 (95% confidence interval 0.33-0.89; p = 0.02). The association was stable across a comprehensive set of adjustments, including length of gestation, mode of delivery, and maternal health indicators (e.g., asthma, smoking, pre-pregnancy body mass index and weight gain during pregnancy, infections, medication, healthy diet, stress), as well as various family environment variables.

Conclusions: Maternal physical activity during pregnancy may be associated with marked protection of asthma in childhood and should be studied further as an applicable measure for asthma prevention.

Funding: The study has been financially supported by grants from the Academy of Finland (no. 349427), the Emil Aaltonen Foundation, the Finnish Cultural Foundation, the Yrjö Jahnsson Foundation, the Juho Vainio Foundation (no. 202200461), the Kuopio Area Respiratory Foundation, and the Ida Montini Foundation.

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来源期刊
Med
Med MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
17.70
自引率
0.60%
发文量
102
期刊介绍: Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.
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