基于线粒体的中枢神经系统疾病细胞器疗法。

IF 8.2 2区 生物学 Q1 CELL BIOLOGY Cell Communication and Signaling Pub Date : 2024-10-10 DOI:10.1186/s12964-024-01843-z
Mengke Zhao, Jiayi Wang, Shuaiyu Zhu, Meina Wang, Chong Chen, Liang Wang, Jing Liu
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引用次数: 0

摘要

由于治疗中枢神经系统(CNS)疾病的传统药物大多治疗靶点单一,许多药物无法治疗复杂疾病或机制不明的疾病,也无法有效逆转 CNS 疾病的根本病变。这就提出了中枢神经系统疾病的复杂病理过程是否涉及多种功能成分的问题。细胞器是细胞的核心功能单元,用健康的细胞器替代受损的细胞器可以多靶点、综合地调节细胞功能。针对细胞内独立功能单元的疗法,特别是基于细胞器的疗法,正在迅速发展。线粒体是中枢神经系统疾病中最重要的细胞器之一,本文全面论述了线粒体平衡失调的发病机制、基于线粒体疗法的机理,以及目前针对线粒体治疗中枢神经系统疾病疗效的临床前和临床研究,为未来使用基于细胞器的治疗策略提供证据。
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Mitochondrion-based organellar therapies for central nervous system diseases.

As most traditional drugs used to treat central nervous system (CNS) diseases have a single therapeutic target, many of them cannot treat complex diseases or diseases whose mechanism is unknown and cannot effectively reverse the root changes underlying CNS diseases. This raises the question of whether multiple functional components are involved in the complex pathological processes of CNS diseases. Organelles are the core functional units of cells, and the replacement of damaged organelles with healthy organelles allows the multitargeted and integrated modulation of cellular functions. The development of therapies that target independent functional units in the cell, specifically, organelle-based therapies, is rapidly progressing. This article comprehensively discusses the pathogenesis of mitochondrial homeostasis disorders, which involve mitochondria, one of the most important organelles in CNS diseases, and the machanisms of mitochondrion-based therapies, as well as current preclinical and clinical studies on the efficacy of therapies targeting mitochondrial to treat CNS diseases, to provide evidence for use of organelle-based treatment strategies in the future.

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来源期刊
CiteScore
11.00
自引率
0.00%
发文量
180
期刊介绍: Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.
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