Minako Narita, Dr. Ai Kohata, Taiichi Kageyama, Honoka Watanabe, Dr. Kohsuke Aikawa, Prof. Dr. Daisuke Kawaguchi, Dr. Kunihiko Morihiro, Prof. Dr. Akimitsu Okamoto, Dr. Takashi Okazoe
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引用次数: 0
摘要
我们合成了几种 RF-DNA 共轭物，并系统地研究了吸收效率与理化性质之间的关系。在 DNA 链的末端带有两个 C8F17 基团的 RF-DNA 共轭物形成了 DNA 含量最高的纳米组装体，通过清道夫受体被细胞吸收的可能性最大。更多详情请见 Ai Kohata、Kohsuke Aikawa 及合作者的文章 10.1002/cbic.202400436。
Front Cover: Fluorocarbon-DNA Conjugates for Enhanced Cellular Delivery: Formation of a Densely Packed DNA Nano-Assembly (ChemBioChem 19/2024)
Several RF-DNA conjugates are synthesized, and the relationship between the uptake efficiency and the physicochemical properties is systematically investigated. RF-DNA conjugates carrying two C8F17 groups at the terminus of a DNA strand form a nano-assembly with the highest DNA content, leading to the greatest cellular uptake via scavenger receptors. More details can be found in article 10.1002/cbic.202400436 by Ai Kohata, Kohsuke Aikawa, and co-workers.
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ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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