Minako Narita, Dr. Ai Kohata, Taiichi Kageyama, Honoka Watanabe, Dr. Kohsuke Aikawa, Prof. Dr. Daisuke Kawaguchi, Dr. Kunihiko Morihiro, Prof. Dr. Akimitsu Okamoto, Dr. Takashi Okazoe
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引用次数: 0
摘要
我们合成了几种 RF-DNA 共轭物，并系统地研究了吸收效率与理化性质之间的关系。在 DNA 链的末端带有两个 C8F17 基团的 RF-DNA 共轭物形成了 DNA 含量最高的纳米组装体，通过清道夫受体被细胞吸收的可能性最大。更多详情请见 Ai Kohata、Kohsuke Aikawa 及合作者的文章 10.1002/cbic.202400436。
Front Cover: Fluorocarbon-DNA Conjugates for Enhanced Cellular Delivery: Formation of a Densely Packed DNA Nano-Assembly (ChemBioChem 19/2024)
Several RF-DNA conjugates are synthesized, and the relationship between the uptake efficiency and the physicochemical properties is systematically investigated. RF-DNA conjugates carrying two C8F17 groups at the terminus of a DNA strand form a nano-assembly with the highest DNA content, leading to the greatest cellular uptake via scavenger receptors. More details can be found in article 10.1002/cbic.202400436 by Ai Kohata, Kohsuke Aikawa, and co-workers.
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