Haizhen Liang , Fan Yang , Jie Zhang, Pengxin Lu, Guang Yang, Xiaojuan Chen, Qing Sun, Juan Song, Shuchen Liu, Baiping Ma
{"title":"基于特征分子网络从 Xanthoceras sorbifolia Bunge 外皮中定向分离出类似巴戟天的三萜类化合物及其抗肿瘤活性。","authors":"Haizhen Liang , Fan Yang , Jie Zhang, Pengxin Lu, Guang Yang, Xiaojuan Chen, Qing Sun, Juan Song, Shuchen Liu, Baiping Ma","doi":"10.1016/j.fitote.2024.106245","DOIUrl":null,"url":null,"abstract":"<div><div>The husks of <em>Xanthoceras sorbifolia</em> Bunge have gradually attracted widespread attention in recent years due to the abundant resources and ideal pharmacological activities, with barrigenol-like triterpenoid saponins being its biological constituents. In this study, a feature-based molecular networking (FBMN) was utilized to perform the targeted isolation of triterpenoids. As a result, six undescribed barrigenol-type saponins (<strong>1–6</strong>) along with fourteen known analogues (<strong>7–22</strong>) were isolated from the extract of <em>X. sorbifolia</em> husk. Their structures were determined through a comprehensive analysis of NMR and HRMS spectroscopic data. Among them, compounds <strong>1–3</strong> are a specific type of saponin featuring a fucose moiety attached at C-21. The antitumor activities of isolated compounds were evaluated and compounds <strong>7</strong>, <strong>9</strong> and <strong>10</strong> showed significant inhibitory activities against A549 and HepG2 cell lines in a dose-dependent manner.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106245"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeted isolation of barrigenol-like triterpenoids from the husks of Xanthoceras sorbifolia Bunge based on feature-based molecular networking and their antitumor activities\",\"authors\":\"Haizhen Liang , Fan Yang , Jie Zhang, Pengxin Lu, Guang Yang, Xiaojuan Chen, Qing Sun, Juan Song, Shuchen Liu, Baiping Ma\",\"doi\":\"10.1016/j.fitote.2024.106245\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The husks of <em>Xanthoceras sorbifolia</em> Bunge have gradually attracted widespread attention in recent years due to the abundant resources and ideal pharmacological activities, with barrigenol-like triterpenoid saponins being its biological constituents. In this study, a feature-based molecular networking (FBMN) was utilized to perform the targeted isolation of triterpenoids. As a result, six undescribed barrigenol-type saponins (<strong>1–6</strong>) along with fourteen known analogues (<strong>7–22</strong>) were isolated from the extract of <em>X. sorbifolia</em> husk. Their structures were determined through a comprehensive analysis of NMR and HRMS spectroscopic data. Among them, compounds <strong>1–3</strong> are a specific type of saponin featuring a fucose moiety attached at C-21. The antitumor activities of isolated compounds were evaluated and compounds <strong>7</strong>, <strong>9</strong> and <strong>10</strong> showed significant inhibitory activities against A549 and HepG2 cell lines in a dose-dependent manner.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":\"179 \",\"pages\":\"Article 106245\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24004283\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004283","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Targeted isolation of barrigenol-like triterpenoids from the husks of Xanthoceras sorbifolia Bunge based on feature-based molecular networking and their antitumor activities
The husks of Xanthoceras sorbifolia Bunge have gradually attracted widespread attention in recent years due to the abundant resources and ideal pharmacological activities, with barrigenol-like triterpenoid saponins being its biological constituents. In this study, a feature-based molecular networking (FBMN) was utilized to perform the targeted isolation of triterpenoids. As a result, six undescribed barrigenol-type saponins (1–6) along with fourteen known analogues (7–22) were isolated from the extract of X. sorbifolia husk. Their structures were determined through a comprehensive analysis of NMR and HRMS spectroscopic data. Among them, compounds 1–3 are a specific type of saponin featuring a fucose moiety attached at C-21. The antitumor activities of isolated compounds were evaluated and compounds 7, 9 and 10 showed significant inhibitory activities against A549 and HepG2 cell lines in a dose-dependent manner.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
