对接受冠状动脉计算机断层扫描血管造影术的患者中心房颤动与肝纤维化-4指数之间关系的调查。

IF 4.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Hypertension Research Pub Date : 2024-10-12 DOI:10.1038/s41440-024-01917-y
Tetsuo Hirata, Yuhei Shiga, Kohei Tashiro, Sara Higashi, Tetsuro Tachibana, Yuto Kawahira, Yasunori Suematsu, Takashi Kuwano, Makoto Sugihara, Masahiro Ogawa, Shin-Ichiro Miura
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引用次数: 0

摘要

肝纤维化评分,如肝纤维化-4指数(FIB-4I),是肝纤维化的代表性指标,最近被认为与心力衰竭、冠状动脉疾病(CAD)和心房颤动(AF)有关。我们研究了接受冠状动脉计算机断层扫描(CCTA)的患者的 FIB-4I 与房颤之间的关系。这项研究包括 1525 名临床怀疑患有 CAD 或即将接受房颤治疗(如导管消融)的患者。FIB-4I和房颤的存在与否是主要终点。房颤组的 FIB-4I 高于窦性心律组(1.93 ± 0.94 对 [vs.] 1.75 ± 1.03,p = 0.001)。阵发性房颤组和持续性房颤组的 FIB-4I 无明显差异(1.93 ± 0.99 vs. 1.94 ± 0.78,p = 0.922)。此外,高血压(HTN)组的 FIB-4I 比非高血压组高(1.84 ± 1.04 vs. 1.62 ± 0.91,p = 0.922)。
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An investigation of the association between atrial fibrillation and the liver fibrosis-4 index in patients who underwent coronary computed tomography angiography.

Liver fibrosis scores, such as the fibrosis-4 index (FIB-4I), a representative index of liver fibrosis, have recently been linked to heart failure, coronary artery disease (CAD), and atrial fibrillation (AF). We investigated the association between FIB-4I and AF in patients who underwent coronary computed tomography angiography (CCTA). This study included 1525 patients clinically suspected of having CAD or about to undergo treatment for AF, such as catheter ablation. FIB-4I and the presence or absence of AF were the primary endpoints. FIB-4I was higher in the AF group than in the sinus rhythm group (1.93 ± 0.94 versus [vs.] 1.75 ± 1.03, p = 0.001). No significant difference was observed in the FIB-4I between the paroxysmal AF and persistent AF groups (1.93 ± 0.99 vs. 1.94 ± 0.78, p = 0.922). Furthermore, FIB-4I was higher in the hypertension (HTN) group than in the non-HTN group (1.84 ± 1.04 vs. 1.62 ± 0.91, p < 0.001). Low FIB-4I (≤1.29) was proven to be a contributing factor for the absence of AF in all patients (odds ratio [OR]: 0.55, 95% confidence interval [CI]: 0.39-0.78, p < 0.001) as well as the HTN and non-HTN (OR: 0.53, 95% CI: 0.37-0.78, p < 0.001 and OR: 0.39, 95% CI: 0.23-0.68, p < 0.001, respectively) groups. Thus, FIB-4I may serve as a diagnostic indicator of the absence of AF in patients undergoing CCTA. The liver fibrosis-4 index as a diagnostic indicator of the absence of atrial fibrillation in patients undergoing coronary computed tomography angiography.

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来源期刊
Hypertension Research
Hypertension Research 医学-外周血管病
CiteScore
7.40
自引率
16.70%
发文量
249
审稿时长
3-8 weeks
期刊介绍: Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.
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