核心的 B 细胞：根尖周病变的免疫机制和治疗潜力。

IF 3.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of endodontics Pub Date : 2024-10-09 DOI:10.1016/j.joen.2024.10.003

Yangqing Peng, Liu Liu, Xiangfen Li, Dongzhe Song, Dingming Huang

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引用次数: 0

摘要

简介：根尖周病变（PL）是一种常见的炎症性疾病，主要由根管中的微生物感染引起。这些感染会引发根尖周组织复杂的免疫反应，其中 B 淋巴细胞扮演着双重角色：既要抵御病原体，又要造成组织损伤。这凸显了 B 细胞在根尖周免疫过程中的关键作用：方法：使用 PubMed、Web of Science、Scopus 和 ScienceDirect 数据库对 PLs 中 B 细胞的相关文献进行了全面综述：结果：综述包括 123 项研究，这些研究探讨了 B 细胞的分布和亚型、它们在 PLs 中的双重功能以及 B 细胞相关疗法在治疗根尖牙周炎中的潜在应用：本综述加深了我们对牙髓炎复杂免疫机制的了解，有助于从 B 细胞角度开发新的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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B Cells at the Core: Immune Mechanisms and Therapeutic Potentials in Periapical Lesions.

Introduction: Periapical lesions (PLs) are common inflammatory diseases primarily caused by microbial infections within root canals. These infections trigger complex immune responses in periapical tissues, with B lymphocytes playing dual roles: defending against pathogens while also contributing to tissue damage. This highlights the crucial role of B cells in the immunological processes of PLs.

Method: A comprehensive review of the literature on B cells in PLs was conducted using PubMed, Web of Science, Scopus, and ScienceDirect databases.

Results: The review included 123 studies that examined the distribution and subtypes of B cells, their dual functions in PLs, and the potential applications of B-cell-related therapies in treating apical periodontitis.

Conclusion: This review enhances our understanding of the complex immune mechanisms in PLs and aids in the development of new therapeutic approaches from a B-cell perspective.

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来源期刊

Journal of endodontics 医学-牙科与口腔外科

CiteScore

8.80

自引率

9.50%

发文量

224

审稿时长

42 days

期刊介绍： The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.