感染性神经病。

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Seminars in Neurology Pub Date : 2024-10-11 DOI:10.1055/s-0044-1791693
Mitali Mehta, Jessica Robinson-Papp
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引用次数: 0

摘要

这篇综述探讨了外周神经系统(PNS)功能障碍的各种感染病因,涉及感觉和运动神经元、神经及相关结构。病毒和细菌感染方面的研究进展揭示了神经病变的多方面机制,包括病毒性神经毒性和免疫介导反应。最新诊断技术的进步有助于早期发现 PNS 并发症,而正在进行的研究则提供了前景广阔的治疗途径。严重急性呼吸系统综合征冠状病毒 2、寨卡病毒和 EV-D68 等新兴病原体凸显了不断发展的感染性神经病模式。识别特征模式和整合临床因素对于精确诊断和有针对性的干预至关重要。由于致病机制不同,评估和管理方面的挑战依然存在。对致病机理的深入了解改善了靶向疗法,但在有效治疗方面仍存在差距。持续的研究对于优化治疗方法和改善患者预后至关重要。
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Infectious Neuropathies.

This review explores diverse infectious etiologies of peripheral nervous system (PNS) dysfunction, spanning sensory and motor neurons, nerves, and associated structures. Progress in viral and bacterial infections reveals multifaceted mechanisms underlying neuropathies, including viral neurotoxicity and immune-mediated responses. Latest diagnostic advances facilitate early PNS complication detection, with ongoing research offering promising treatment avenues. Emerging pathogens like severe acute respiratory syndrome coronavirus 2, Zika virus, and EV-D68 highlight the evolving infectious neuropathy paradigm. Recognizing characteristic patterns and integrating clinical factors are pivotal for precise diagnosis and tailored intervention. Challenges persist in assessment and management due to varied pathogenic mechanisms. Advancements in understanding pathogenesis have improved targeted therapies, yet gaps remain in effective treatments. Ongoing research is crucial for optimizing approaches and improving patient outcomes.

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来源期刊
Seminars in Neurology
Seminars in Neurology 医学-临床神经学
CiteScore
4.60
自引率
3.70%
发文量
65
审稿时长
6-12 weeks
期刊介绍: Seminars in Neurology is a review journal on current trends in the evaluation, diagnosis, and treatment of neurological diseases. Areas of coverage include multiple sclerosis, central nervous system infections, muscular dystrophy, neuro-immunology, spinal disorders, strokes, epilepsy, motor neuron diseases, movement disorders, higher cortical function, neuro-genetics and neuro-ophthamology. Each issue is presented under the direction of an expert guest editor, and invited contributors focus on a single, high-interest clinical topic. Up-to-the-minute coverage of the latest information in the field makes this journal an invaluable resource for neurologists and residents.
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