比较关节镜下肩关节唇脱位修复术和非手术疗法治疗年轻患者原发性肩关节前脱位的复发率和成本效益

Jacob F. Oeding, William R. Schulz, Allen S. Wang, Aaron J. Krych, Dean C. Taylor, Kristian Samuelsson, Christopher L. Camp, Adam J. Tagliero
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Tagliero","doi":"10.1177/03635465241282342","DOIUrl":null,"url":null,"abstract":"Background:Value-based decision-making regarding nonoperative management versus early surgical stabilization for first-time anterior shoulder instability (ASI) events remains understudied.Purpose:To perform (1) a systematic review of the current literature and (2) a Markov model–based cost-effectiveness analysis comparing an initial trial of nonoperative management to arthroscopic Bankart repair (ABR) for first-time ASI.Study Design:Economic and decision analysis; Level of evidence, 3.Methods:A Markov chain Monte Carlo probabilistic model was developed to evaluate the outcomes and costs of 1000 simulated patients (mean age, 20 years; range, 12-26 years) with first-time ASI undergoing nonoperative management versus ABR. Utility values, recurrence rates, and transition probabilities were derived from the published literature. Costs were determined based on the typical patient undergoing each treatment strategy at the authors’ institution. Outcome measures included costs, quality-adjusted life-years (QALYs), and the incremental cost-effectiveness ratio (ICER).Results:The Markov model with Monte Carlo microsimulation demonstrated mean (± standard deviation) 10-year costs for nonoperative management and ABR of $38,649 ± $10,521 and $43,052 ± $9352, respectively. Total QALYs acquired over the 10-year time horizon were 7.67 ± 0.43 and 8.44 ± 0.46 for nonoperative management and ABR, respectively. The ICER comparing ABR with nonoperative management was found to be just $5725/QALY, which falls substantially below the $50,000 willingness-to-pay (WTP) threshold. The mean numbers of recurrences were 2.55 ± 0.31 and 1.17 ± 0.18 for patients initially assigned to the nonoperative and ABR treatment groups, respectively. 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研究目的:(1)对现有文献进行系统回顾;(2)基于马尔可夫模型进行成本效益分析,比较非手术治疗与关节镜下Bankart修复术(ABR)治疗首次肩关节前不稳定事件的初步试验。研究设计:经济和决策分析;证据级别:3。方法:建立了一个马尔可夫链蒙特卡洛概率模型,以评估1000名模拟患者(平均年龄20岁;范围12-26岁)首次ASI接受非手术治疗与ABR治疗的结果和成本。效用值、复发率和转变概率均来自已发表的文献。费用是根据作者所在机构接受每种治疗策略的典型患者的情况确定的。结果:采用蒙特卡洛微观模拟的马尔可夫模型显示,非手术治疗和ABR的10年平均成本(±标准差)分别为38649美元±10521美元和43052美元±9352美元。非手术治疗和 ABR 的 10 年总 QALY 分别为 7.67 ± 0.43 和 8.44 ± 0.46。研究发现,ABR 与非手术治疗的 ICER 仅为 5725 美元/QALY,大大低于 50,000 美元的支付意愿(WTP)阈值。最初被分配到非手术治疗组和ABR治疗组的患者的平均复发次数分别为2.55 ± 0.31和1.17 ± 0.18。结论:对于年轻患者的首次人工关节置换,ABR 可降低复发脱位的风险,尽管与非手术治疗相比,ABR 的前期费用更高,但其成本效益更高。虽然所有这些因素都是手术决策中需要考虑的重要因素,但最终的治疗决策应根据个体情况,通过共同决策过程做出。
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Comparing Recurrence Rates and Cost-Effectiveness of Arthroscopic Labral Repair and Nonoperative Management for Primary Anterior Shoulder Dislocations in Young Patients
Background:Value-based decision-making regarding nonoperative management versus early surgical stabilization for first-time anterior shoulder instability (ASI) events remains understudied.Purpose:To perform (1) a systematic review of the current literature and (2) a Markov model–based cost-effectiveness analysis comparing an initial trial of nonoperative management to arthroscopic Bankart repair (ABR) for first-time ASI.Study Design:Economic and decision analysis; Level of evidence, 3.Methods:A Markov chain Monte Carlo probabilistic model was developed to evaluate the outcomes and costs of 1000 simulated patients (mean age, 20 years; range, 12-26 years) with first-time ASI undergoing nonoperative management versus ABR. Utility values, recurrence rates, and transition probabilities were derived from the published literature. Costs were determined based on the typical patient undergoing each treatment strategy at the authors’ institution. Outcome measures included costs, quality-adjusted life-years (QALYs), and the incremental cost-effectiveness ratio (ICER).Results:The Markov model with Monte Carlo microsimulation demonstrated mean (± standard deviation) 10-year costs for nonoperative management and ABR of $38,649 ± $10,521 and $43,052 ± $9352, respectively. Total QALYs acquired over the 10-year time horizon were 7.67 ± 0.43 and 8.44 ± 0.46 for nonoperative management and ABR, respectively. The ICER comparing ABR with nonoperative management was found to be just $5725/QALY, which falls substantially below the $50,000 willingness-to-pay (WTP) threshold. The mean numbers of recurrences were 2.55 ± 0.31 and 1.17 ± 0.18 for patients initially assigned to the nonoperative and ABR treatment groups, respectively. Of 1000 samples run over 1000 trials, ABR was the optimal strategy in 98.7% of cases, with nonoperative management the optimal strategy in 1.3% of cases.Conclusion:ABR reduces the risk for recurrent dislocations and is more cost-effective despite higher upfront costs when compared with nonoperative management for first-time ASI in the young patient. While all these factors are important to consider in surgical decision-making, ultimate treatment decisions should be made on an individual basis and occur through a shared decision-making process.
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