心灵、大脑和身体研究:研究肠道-大脑-免疫轴对遭受与照料有关的早期逆境的青少年内化症状的影响的方案

IF 3.7 Q2 IMMUNOLOGY Brain, behavior, & immunity - health Pub Date : 2024-10-05 DOI:10.1016/j.bbih.2024.100880
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引用次数: 0

摘要

与照顾相关的逆境经历很常见,也是内化心理病理学(即焦虑和抑郁)的最强预测因素之一。具体来说,经历过这种早期逆境的个体,其情感神经发育会发生改变,记忆系统受损,患内化障碍的风险增加,炎症加剧,胃肠道(肠道)微生物组的组成也会出现差异。至关重要的是,肠道微生物组的发育敏感期早于神经和免疫敏感期,因此肠道微生物组有可能成为富有成效的干预目标。尽管之前的研究已经对早期逆境个体的神经、免疫和肠道微生物组系统进行了评估,但这些研究主要是单独研究这些生物系统。心智、大脑和身体研究(MBB)采用了多模式和纵向设计,以评估与照顾相关的逆境之后肠道微生物组的变化如何导致青少年情感神经发育、记忆和免疫功能的改变,以及如何导致内化症状。在相隔约 12-18 个月的三轮研究中,有和没有照顾相关逆境经历的青少年完成了心理和身体健康的自我报告测量,提供了粪便、唾液、头发和血液样本,并完成了核磁共振成像扫描。这项研究的结果将扩展我们对肠道微生物组如何影响多个生物和认知系统的认识,并激励我们今后将肠道微生物组作为潜在干预目标进行研究。
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The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity
Experiences of caregiving-related adversity are common and one of the strongest predictors of internalizing psychopathology (i.e., anxiety and depression). Specifically, individuals who have been exposed to such early adversities have altered affective neurodevelopment, impaired memory systems, increased risk of developing internalizing disorders, greater inflammation, and differences in gastrointestinal (gut) microbiome composition. Crucially, the gut microbiome undergoes a sensitive period of development that precedes neural and immune sensitive periods, thus making it a potentially fruitful target for intervention. Though previous work has assessed neural, immune, and gut microbiome systems in individuals exposed to early adversity, studies have primarily looked at these biological systems independently. The Mind, Brain, and Body study (MBB) implements multimodal and longitudinal design to assess how changes in the gut microbiome following caregiving-related adversity may underlie altered affective neurodevelopment, memory, and immune functioning in youth and contribute to internalizing symptoms. Across three waves, spread approximately 12–18 months apart, youth with and without previous experiences of caregiving-related adversity completed self-report measures of mental and physical health, provided stool, saliva, hair, and blood samples, and completed an MRI scan. Results of this study will expand our knowledge on how the gut microbiome shapes several biological and cognitive systems and motivate future work investigating the gut microbiome as potential target for intervention.
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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
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0
审稿时长
97 days
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