二氧化钛纳米颗粒与高浓度二氧化碳对金鱼的遗传毒性

IF 2.3 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation research. Genetic toxicology and environmental mutagenesis Pub Date : 2024-09-28 DOI:10.1016/j.mrgentox.2024.503826

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引用次数: 0

摘要

二氧化钛纳米粒子具有光催化作用，可产生活性氧，对水生生物群落有害。我们研究了 nTiO2 与水中高浓度 CO2 结合产生的毒性效应。我们将金鱼暴露在与环境相关的二氧化钛浓度和二氧化碳浓度下。彗星试验结果表明，高浓度二氧化碳会增加DNA断裂，但二氧化钛浓度没有影响。微核试验显示没有明显的微核形成。鱼鳃出现了组织病理学变化，但肝脏没有。

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Genotoxicity in the goldfish of TiO2 nanoparticles combined with high CO2 levels

TiO₂ nanoparticles are photocatalytic, generate reactive oxygen, and can be harmful to aquatic biota. We have studied the toxic effects of nTiO₂ combined with high CO₂ levels in water. We exposed goldfish to environmentally relevant concentrations of nTiO₂ and CO₂ levels. Comet assay results showed that DNA breaks increased at high CO₂ concentration, but no effect of nTiO₂ concentrations was seen. Micronucleus assays showed no significant micronucleus formation. Histopathological alterations were seen in the gills but not in the liver.

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来源期刊

Mutation research. Genetic toxicology and environmental mutagenesis 生物-毒理学

CiteScore

3.80

自引率

5.30%

发文量

审稿时长

105 days

期刊介绍： Mutation Research - Genetic Toxicology and Environmental Mutagenesis (MRGTEM) publishes papers advancing knowledge in the field of genetic toxicology. Papers are welcomed in the following areas: New developments in genotoxicity testing of chemical agents (e.g. improvements in methodology of assay systems and interpretation of results). Alternatives to and refinement of the use of animals in genotoxicity testing. Nano-genotoxicology, the study of genotoxicity hazards and risks related to novel man-made nanomaterials. Studies of epigenetic changes in relation to genotoxic effects. The use of structure-activity relationships in predicting genotoxic effects. The isolation and chemical characterization of novel environmental mutagens. The measurement of genotoxic effects in human populations, when accompanied by quantitative measurements of environmental or occupational exposures. The application of novel technologies for assessing the hazard and risks associated with genotoxic substances (e.g. OMICS or other high-throughput approaches to genotoxicity testing). MRGTEM is now accepting submissions for a new section of the journal: Current Topics in Genotoxicity Testing, that will be dedicated to the discussion of current issues relating to design, interpretation and strategic use of genotoxicity tests. This section is envisaged to include discussions relating to the development of new international testing guidelines, but also to wider topics in the field. The evaluation of contrasting or opposing viewpoints is welcomed as long as the presentation is in accordance with the journal''s aims, scope, and policies.