Le-Song Wu, Chen-Yue Wang, Tao Zhou, Bing-Feng Shi
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Pd(II)-Catalyzed Chemo-, Diastereo-, and Enantioselective C(sp3)–H Arylation to Construct Contiguous Phosphorus and Carbon Stereocenters
Chiral phosphorus compounds with contiguous P,C-stereogenic centers are widely found in chiral ligands. The synthesis of these skeletons has been scarcely reported. Herein, we developed a Pd(II)-catalyzed chemo-, diastereo-, and enantioselective arylation of diisopropyl phosphinamide enabled by 2-pyridinylisopropyl (PIP) auxiliary and (S)-6,6′-(CN)2-SPINOL. A range of chiral phosphinamides containing contiguous P,C-stereocenters were obtained in good yields (up to 85%) with excellent enantioselectivities (up to >99% ee).
期刊介绍:
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.