BCAS1+ 少突胶质细胞有助于多发性硬化症的髓鞘再形成

IF 28.2 1区 医学 Q1 CLINICAL NEUROLOGY Nature Reviews Neurology Pub Date : 2024-10-14 DOI:10.1038/s41582-024-01031-0
Heather Wood
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引用次数: 0

摘要

最近的一份报告确定了大脑皮层中表达脑富集髓鞘相关蛋白1(BCAS1)的少突胶质细胞群,它们似乎有助于多发性硬化症(MS)的再髓鞘化。对多发性硬化症早期患者和脱髓鞘小鼠模型的大脑皮层组织进行分析后发现,BCAS1+少突胶质细胞数量丰富,并在脱髓鞘事件发生时呈现活化的髓鞘化形态。然而,在慢性多发性硬化症患者中,皮质BCAS1+少突胶质细胞的数量减少了,这可能有助于解释为什么再髓鞘化在疾病晚期会失败。
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来源期刊
Nature Reviews Neurology
Nature Reviews Neurology 医学-临床神经学
CiteScore
29.90
自引率
0.80%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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