Xiang-Da Li , Yan-Gang Cao , Yu-Han Zhang , Ying-Jie Ren , Meng-Nan Zeng , Yan-Ling Liu , Xu Chen , Xin-Yi Ma , Bing-Xian Zhao , Xiao-Ke Zheng , Wei-Sheng Feng
{"title":"地黄鲜根中的类胡萝卜素及其抗肺纤维化活性","authors":"Xiang-Da Li , Yan-Gang Cao , Yu-Han Zhang , Ying-Jie Ren , Meng-Nan Zeng , Yan-Ling Liu , Xu Chen , Xin-Yi Ma , Bing-Xian Zhao , Xiao-Ke Zheng , Wei-Sheng Feng","doi":"10.1016/j.fitote.2024.106247","DOIUrl":null,"url":null,"abstract":"<div><div>Six undescribed compounds (<strong>1</strong>–<strong>6</strong>) and twenty-three known analogues (<strong>7</strong>–<strong>29</strong>) were isolated from the fresh roots of <em>Rehmannia glutinosa</em>. The structures of the compounds (<strong>1</strong>–<strong>29</strong>) were established through the application of spectroscopic analysis. Compounds <strong>3</strong>, <strong>4</strong>, <strong>6</strong>, <strong>8</strong>, <strong>13</strong>, <strong>18</strong>, <strong>21</strong>, <strong>22</strong>, <strong>25</strong>, and <strong>28</strong> exhibited excellent anti-pulmonary fibrosis activity. The potential mechanistic pathway of <strong>3</strong> was also investigated, whose results indicate that compound <strong>3</strong> ameliorate TGF-β1 induced BEAS-2B cell injury via PI3K/AKT/NF-κB signaling pathway.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106247"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Apocarotenoids from the fresh roots of Rehmannia glutinosa and their anti-pulmonary fibrosis activity\",\"authors\":\"Xiang-Da Li , Yan-Gang Cao , Yu-Han Zhang , Ying-Jie Ren , Meng-Nan Zeng , Yan-Ling Liu , Xu Chen , Xin-Yi Ma , Bing-Xian Zhao , Xiao-Ke Zheng , Wei-Sheng Feng\",\"doi\":\"10.1016/j.fitote.2024.106247\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Six undescribed compounds (<strong>1</strong>–<strong>6</strong>) and twenty-three known analogues (<strong>7</strong>–<strong>29</strong>) were isolated from the fresh roots of <em>Rehmannia glutinosa</em>. The structures of the compounds (<strong>1</strong>–<strong>29</strong>) were established through the application of spectroscopic analysis. Compounds <strong>3</strong>, <strong>4</strong>, <strong>6</strong>, <strong>8</strong>, <strong>13</strong>, <strong>18</strong>, <strong>21</strong>, <strong>22</strong>, <strong>25</strong>, and <strong>28</strong> exhibited excellent anti-pulmonary fibrosis activity. The potential mechanistic pathway of <strong>3</strong> was also investigated, whose results indicate that compound <strong>3</strong> ameliorate TGF-β1 induced BEAS-2B cell injury via PI3K/AKT/NF-κB signaling pathway.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":\"179 \",\"pages\":\"Article 106247\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24004301\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004301","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Apocarotenoids from the fresh roots of Rehmannia glutinosa and their anti-pulmonary fibrosis activity
Six undescribed compounds (1–6) and twenty-three known analogues (7–29) were isolated from the fresh roots of Rehmannia glutinosa. The structures of the compounds (1–29) were established through the application of spectroscopic analysis. Compounds 3, 4, 6, 8, 13, 18, 21, 22, 25, and 28 exhibited excellent anti-pulmonary fibrosis activity. The potential mechanistic pathway of 3 was also investigated, whose results indicate that compound 3 ameliorate TGF-β1 induced BEAS-2B cell injury via PI3K/AKT/NF-κB signaling pathway.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
