空气中的罪魁祸首:全面回顾可吸入颗粒物、二氧化硅和 TCDD 与自身免疫性疾病的关系

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2024-10-10 DOI:10.1016/j.jtauto.2024.100253
Daniel Galeano-Sánchez, Victoria Morales-González, Diana M. Monsalve, Carolina Ramırez-Santana, Yeny Acosta-Ampudia
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引用次数: 0

摘要

自身免疫性疾病(ADs)是受各种内部和外部因素影响,因免疫耐受破坏而引起的免疫紊乱。本综述通过分析流行病学研究、动物模型和体外试验,探讨了空气污染物(包括颗粒物、二氧化硅和 TCDD)的影响。研究重点是空气污染如何扰乱免疫系统,导致细胞凋亡、氧化应激增加、细胞因子产生、自身抗原释放、自身抗体产生和自身反应性,这在类风湿性关节炎、系统性红斑狼疮、斯约格伦综合征和系统性硬化症等注意力缺失症中尤为显著。从本质上讲,这种方法旨在让人们深刻理解暴露于空气污染会如何引发或导致注意力缺失症,从而为更有针对性的预防和治疗策略提供潜在的途径。
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Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases
Autoimmune diseases (ADs) are immunological disorders arising from the breakdown of immune tolerance, influenced by various internal and external factors. Persistent exposure to environmental factors, particularly air pollution, is linked to systemic inflammation, oxidative stress, and apoptosis, which contribute to the development of ADs.
This review examines the impact of air pollutants, including particulate matter, silica, and TCDD, by analyzing epidemiological studies, animal models, and in vitro assays. It focuses on how air pollution disrupts the immune system, leading to apoptosis, increased oxidative stress, cytokine production, autoantigen release, autoantibody production, and autoreactivity, which are particularly significant in ADs like rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis. In essence, this approach aims to provide a profound understanding of how exposure to air pollution can initiate or contribute to ADs, offering potential avenues for more targeted preventive and therapeutic strategies.
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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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