MICU1 和 MICU2 是一个豆荚里的两颗豆子,还是完全不同的果实?

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2024-10-08 DOI:10.1016/j.ceca.2024.102959
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引用次数: 0

摘要

线粒体基质 Ca2+ 的波动通过直接影响氧化磷酸化和 ATP 的产生,在使能量产生与细胞需求相匹配方面发挥着至关重要的作用。线粒体 Ca2+ 平衡的破坏,尤其是在缺血或心力衰竭等病理情况下,可导致线粒体功能障碍、能量不足,并最终导致心肌细胞死亡。调节急性线粒体 Ca2+ 流入的主要通道是线粒体 Ca2+ 单通道(mtCU),它受线粒体 Ca2+ 摄取(MICU)蛋白的调节。
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MICU1 and MICU2, two peas in a pod or entirely different fruits?
Fluctuations in mitochondrial matrix Ca2+ plays a critical role in matching energy production to cellular demand through direct effects on oxidative phosphorylation and ATP production. Disruption in mitochondrial Ca2+ homeostasis, particularly under pathological conditions such as ischemia or heart failure, can lead to mitochondrial dysfunction, energy deficit, and eventually death of cardiomyocytes. The primary channel regulating acute mitochondrial Ca2+ influx is the mitochondrial Ca2+ uniporter (mtCU), which is regulated by the mitochondrial Ca2+ uptake (MICU) proteins that were examined here.
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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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