{"title":"钯催化的乙烯基烯烃在水†上的对映选择性酯化反应","authors":"Junhua Li, Yaqian Min and Yian Shi","doi":"10.1039/D4NJ02253J","DOIUrl":null,"url":null,"abstract":"<p >An efficient Pd-catalyzed asymmetric hydroesterification of vinyl arenes on water is reported. A variety of phenyl 2-arylpropanoates can be obtained in good yields with high b/l ratios and ee's with phenyl formate or CO as a carbonyl source. (<em>R</em>)-DTBM-SEGPHOS was found to be an effective ligand for the reaction under aqueous conditions. The hydrophobicity of the ligand appeared to be crucial to the hydroesterification reaction, which likely proceeded “on water”.</p>","PeriodicalId":95,"journal":{"name":"New Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pd-catalyzed enantioselective hydroesterification of vinyl arenes on water†\",\"authors\":\"Junhua Li, Yaqian Min and Yian Shi\",\"doi\":\"10.1039/D4NJ02253J\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >An efficient Pd-catalyzed asymmetric hydroesterification of vinyl arenes on water is reported. A variety of phenyl 2-arylpropanoates can be obtained in good yields with high b/l ratios and ee's with phenyl formate or CO as a carbonyl source. (<em>R</em>)-DTBM-SEGPHOS was found to be an effective ligand for the reaction under aqueous conditions. The hydrophobicity of the ligand appeared to be crucial to the hydroesterification reaction, which likely proceeded “on water”.</p>\",\"PeriodicalId\":95,\"journal\":{\"name\":\"New Journal of Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New Journal of Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/nj/d4nj02253j\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/nj/d4nj02253j","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
本研究报道了在 Pd 催化下,乙烯基烯烃在水中的高效不对称酯化反应。以甲酸苯酯或 CO 为羰基源,可以获得多种 2-芳基丙酸苯酯,产率高,b/l 比和 ee 值高。研究发现,(R)-DTBM-SEGPHOS 是在水性条件下进行反应的有效配体。配体的疏水性似乎对可能在 "水上 "进行的酯化反应至关重要。
Pd-catalyzed enantioselective hydroesterification of vinyl arenes on water†
An efficient Pd-catalyzed asymmetric hydroesterification of vinyl arenes on water is reported. A variety of phenyl 2-arylpropanoates can be obtained in good yields with high b/l ratios and ee's with phenyl formate or CO as a carbonyl source. (R)-DTBM-SEGPHOS was found to be an effective ligand for the reaction under aqueous conditions. The hydrophobicity of the ligand appeared to be crucial to the hydroesterification reaction, which likely proceeded “on water”.