{"title":"新型双-1,3,4-恶二唑、双-1,3,4-噻二唑及其衍生物的合成与抗氧化活性","authors":"S. V. Dilanyan, Zh. M. Buniatyan, H. A. Panosyan","doi":"10.1134/S1070428024070224","DOIUrl":null,"url":null,"abstract":"<p>Bis-1,3,4-oxadiazoles and bis-1,3,4-thiadiazoles with aryl and alkyl linkers have been synthesized. The pharmacophore electron-deficient groups (carboxylic, nitrile) have been introduced into the molecule to increase their hydrophilicity and potential biological activity. Functionalized compounds have demonstrated a new type of biological activity, i.e., inhibition of lipid oxidation revealed as a decrease in the amount of MDA.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Antioxidant Activity of New Bis-1,3,4-oxadiazoles, Bis-1,3,4-thiadiazoles, and Their Derivatives\",\"authors\":\"S. V. Dilanyan, Zh. M. Buniatyan, H. A. Panosyan\",\"doi\":\"10.1134/S1070428024070224\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Bis-1,3,4-oxadiazoles and bis-1,3,4-thiadiazoles with aryl and alkyl linkers have been synthesized. The pharmacophore electron-deficient groups (carboxylic, nitrile) have been introduced into the molecule to increase their hydrophilicity and potential biological activity. Functionalized compounds have demonstrated a new type of biological activity, i.e., inhibition of lipid oxidation revealed as a decrease in the amount of MDA.</p>\",\"PeriodicalId\":766,\"journal\":{\"name\":\"Russian Journal of Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070428024070224\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428024070224","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Synthesis and Antioxidant Activity of New Bis-1,3,4-oxadiazoles, Bis-1,3,4-thiadiazoles, and Their Derivatives
Bis-1,3,4-oxadiazoles and bis-1,3,4-thiadiazoles with aryl and alkyl linkers have been synthesized. The pharmacophore electron-deficient groups (carboxylic, nitrile) have been introduced into the molecule to increase their hydrophilicity and potential biological activity. Functionalized compounds have demonstrated a new type of biological activity, i.e., inhibition of lipid oxidation revealed as a decrease in the amount of MDA.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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