通过脱硝氨基烷基化还原硝基烷烃的同系物反应

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-10-16 DOI:10.1021/acs.orglett.4c03269

Ayumi Osawa, Maanashaa Balasubramanian, Yoshiaki Nakao

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引用次数: 0

摘要

我们介绍了利用反硝化氨基烷基化反应对硝基烷烃进行还原同族反应的方法。这种转化是通过硝基烷烃衍生的烷基自由基与持久性氨基烷基自由基的自由基-自由基偶联实现的。通过利用硝基烷烃的多种 α 功能化，可以很容易地获得 α、β- 多官能胺。

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Reductive Homologation of Nitroalkanes via Denitrative Aminoalkylation

We present the reductive homologation of nitroalkanes through the utilization of the denitrative aminoalkylation reaction. This transformation is accomplished by the radical–radical coupling of alkyl radicals derived from nitroalkanes and persistent aminoalkyl radicals. By capitalizing on the diverse α-functionalization of nitroalkanes, α,β-multifunctionalized amines can be readily accessed.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.