{"title":"镁和钾对 2 型糖尿病患者胆固醇和生活质量的疗效比较：随机单盲对照临床试验","authors":"Sidra Khalid, Riffat Mehboob, Syeda Shazia Bokhari, Muhammad Ali, Ambreen Shabbir, Khurram Mehboob, Hafsa Adnan, Mohammed Matoog Karami, Hani Shalabi, Bander Alshehri","doi":"10.1002/edm2.511","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>Previous studies exploring the relationship between dietary potassium and magnesium intake and the risk of type 2 diabetes mellitus (T2DM) have yielded inconsistent results.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>The present study was designed to compare the effect of magnesium, potassium and both (potassium and magnesium combined) on cholesterol levels and quality of life (QoL) among patients with T2DM.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A randomised controlled trial (single blinded) was conducted at The University of Lahore and Lahore Medical Research Center (LMRC). The sample size was 290 patients with T2DM, who were divided into four groups: Group I (T1) that received control/placebo; Group II (T2) and Group III (T3) received magnesium and potassium supplements, respectively; and Group IV (T4) received both magnesium and potassium supplements. Blood samples were taken from all patients before and after 60 days of supplementation to determine the levels of K<sup>+</sup>, Mg<sup>2+</sup> and cholesterol using a chemistry analyzer (photometer 5010 v5+).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>There was a decrease in mean cholesterol levels in all groups after the treatment, with the largest reduction (224.9 ± 61.92 to 163.4 ± 48.38) seen in the T3 group, that received potassium supplements. A significant increase in the social QoL, indicated by a <i>p</i> value change from 0.06 before medical intervention to 0.000 after medical intervention, was observed. <i>p</i> value was significant (<0.05) between pre- and post-QoL within the T2 (Mg) and T3 (K) treatment groups.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The overall decrease in cholesterol levels and improvement in the social QoL after treatment imply that magnesium- and potassium-based formulations prove beneficial in combating hyperlipidaemia in patients with T2DM.</p>\n \n <p><b>Trial Registration:</b> NCT04642313</p>\n </section>\n </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.511","citationCount":"0","resultStr":"{\"title\":\"Comparative Efficacy of Magnesium and Potassium Towards Cholesterol and Quality of Life in Patients With Type 2 Diabetes Mellitus: A Randomised Single-Blinded Controlled Clinical Trial\",\"authors\":\"Sidra Khalid, Riffat Mehboob, Syeda Shazia Bokhari, Muhammad Ali, Ambreen Shabbir, Khurram Mehboob, Hafsa Adnan, Mohammed Matoog Karami, Hani Shalabi, Bander Alshehri\",\"doi\":\"10.1002/edm2.511\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <p>Previous studies exploring the relationship between dietary potassium and magnesium intake and the risk of type 2 diabetes mellitus (T2DM) have yielded inconsistent results.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>The present study was designed to compare the effect of magnesium, potassium and both (potassium and magnesium combined) on cholesterol levels and quality of life (QoL) among patients with T2DM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A randomised controlled trial (single blinded) was conducted at The University of Lahore and Lahore Medical Research Center (LMRC). The sample size was 290 patients with T2DM, who were divided into four groups: Group I (T1) that received control/placebo; Group II (T2) and Group III (T3) received magnesium and potassium supplements, respectively; and Group IV (T4) received both magnesium and potassium supplements. Blood samples were taken from all patients before and after 60 days of supplementation to determine the levels of K<sup>+</sup>, Mg<sup>2+</sup> and cholesterol using a chemistry analyzer (photometer 5010 v5+).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>There was a decrease in mean cholesterol levels in all groups after the treatment, with the largest reduction (224.9 ± 61.92 to 163.4 ± 48.38) seen in the T3 group, that received potassium supplements. A significant increase in the social QoL, indicated by a <i>p</i> value change from 0.06 before medical intervention to 0.000 after medical intervention, was observed. <i>p</i> value was significant (<0.05) between pre- and post-QoL within the T2 (Mg) and T3 (K) treatment groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>The overall decrease in cholesterol levels and improvement in the social QoL after treatment imply that magnesium- and potassium-based formulations prove beneficial in combating hyperlipidaemia in patients with T2DM.</p>\\n \\n <p><b>Trial Registration:</b> NCT04642313</p>\\n </section>\\n </div>\",\"PeriodicalId\":36522,\"journal\":{\"name\":\"Endocrinology, Diabetes and Metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.511\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrinology, Diabetes and Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/edm2.511\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology, Diabetes and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/edm2.511","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Comparative Efficacy of Magnesium and Potassium Towards Cholesterol and Quality of Life in Patients With Type 2 Diabetes Mellitus: A Randomised Single-Blinded Controlled Clinical Trial
Previous studies exploring the relationship between dietary potassium and magnesium intake and the risk of type 2 diabetes mellitus (T2DM) have yielded inconsistent results.
Objective
The present study was designed to compare the effect of magnesium, potassium and both (potassium and magnesium combined) on cholesterol levels and quality of life (QoL) among patients with T2DM.
Methods
A randomised controlled trial (single blinded) was conducted at The University of Lahore and Lahore Medical Research Center (LMRC). The sample size was 290 patients with T2DM, who were divided into four groups: Group I (T1) that received control/placebo; Group II (T2) and Group III (T3) received magnesium and potassium supplements, respectively; and Group IV (T4) received both magnesium and potassium supplements. Blood samples were taken from all patients before and after 60 days of supplementation to determine the levels of K+, Mg2+ and cholesterol using a chemistry analyzer (photometer 5010 v5+).
Results
There was a decrease in mean cholesterol levels in all groups after the treatment, with the largest reduction (224.9 ± 61.92 to 163.4 ± 48.38) seen in the T3 group, that received potassium supplements. A significant increase in the social QoL, indicated by a p value change from 0.06 before medical intervention to 0.000 after medical intervention, was observed. p value was significant (<0.05) between pre- and post-QoL within the T2 (Mg) and T3 (K) treatment groups.
Conclusions
The overall decrease in cholesterol levels and improvement in the social QoL after treatment imply that magnesium- and potassium-based formulations prove beneficial in combating hyperlipidaemia in patients with T2DM.
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