通过激活生热脂肪组织有效预防和治疗小鼠急性白血病（科学进展 38/2024）

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Science Pub Date : 2024-10-16 DOI:10.1002/advs.202470231

Ruibo Chen, Tianran Cheng, Sisi Xie, Xiaoting Sun, Mingjia Chen, Shumin Zhao, Qingyan Ruan, Xiaolei Ni, Mei Rao, Xinyi Quan, Kaiwen Chen, Shiyue Zhang, Tao Cheng, Yuanfu Xu, Yuguo Chen, Yunlong Yang, Yihai Cao

{"title":"通过激活生热脂肪组织有效预防和治疗小鼠急性白血病（科学进展 38/2024）","authors":"Ruibo Chen, Tianran Cheng, Sisi Xie, Xiaoting Sun, Mingjia Chen, Shumin Zhao, Qingyan Ruan, Xiaolei Ni, Mei Rao, Xinyi Quan, Kaiwen Chen, Shiyue Zhang, Tao Cheng, Yuanfu Xu, Yuguo Chen, Yunlong Yang, Yihai Cao","doi":"10.1002/advs.202470231","DOIUrl":null,"url":null,"abstract":"<p><b>Anti-Leukemia by Activation of Thermogenic Adipose Tissues</b></p><p>In article number 2402332, Yihai Cao, Yunlong Yang, Yuguo Chen, Yuanfu Xu, and colleagues report that activating thermogenic adipose tissues (TATs) by cold exposure or β3-adrenergic receptor agonists markedly alleviated development and progression of acute myeloid leukemia and acute lymphoblastic leukemia. The cover portrays a TAT troop clothed in brown (brown adipocytes) assailing a leukemia cell in an icy and snowy milieu. This study indicate that targeting tissues outside of cancer could be an antileukemia therapy. Art by Zhichao Xu.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":null,"pages":null},"PeriodicalIF":14.3000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202470231","citationCount":"0","resultStr":"{\"title\":\"Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues (Adv. Sci. 38/2024)\",\"authors\":\"Ruibo Chen, Tianran Cheng, Sisi Xie, Xiaoting Sun, Mingjia Chen, Shumin Zhao, Qingyan Ruan, Xiaolei Ni, Mei Rao, Xinyi Quan, Kaiwen Chen, Shiyue Zhang, Tao Cheng, Yuanfu Xu, Yuguo Chen, Yunlong Yang, Yihai Cao\",\"doi\":\"10.1002/advs.202470231\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Anti-Leukemia by Activation of Thermogenic Adipose Tissues</b></p><p>In article number 2402332, Yihai Cao, Yunlong Yang, Yuguo Chen, Yuanfu Xu, and colleagues report that activating thermogenic adipose tissues (TATs) by cold exposure or β3-adrenergic receptor agonists markedly alleviated development and progression of acute myeloid leukemia and acute lymphoblastic leukemia. The cover portrays a TAT troop clothed in brown (brown adipocytes) assailing a leukemia cell in an icy and snowy milieu. This study indicate that targeting tissues outside of cancer could be an antileukemia therapy. Art by Zhichao Xu.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":117,\"journal\":{\"name\":\"Advanced Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":14.3000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202470231\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Science\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/advs.202470231\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202470231","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

激活生热脂肪组织抗白血病在文章编号2402332中，曹义海、杨云龙、陈玉国、徐元富及其同事报道了通过冷暴露或β3-肾上腺素能受体激动剂激活生热脂肪组织（TATs）可明显缓解急性髓性白血病和急性淋巴细胞白血病的发展和恶化。封面描绘了一支身穿棕色衣服的 TAT 部队（棕色脂肪细胞）在冰天雪地中攻击白血病细胞。这项研究表明，以癌症以外的组织为靶点可能是一种抗白血病疗法。美术：徐志超。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues (Adv. Sci. 38/2024)

Anti-Leukemia by Activation of Thermogenic Adipose Tissues

In article number 2402332, Yihai Cao, Yunlong Yang, Yuguo Chen, Yuanfu Xu, and colleagues report that activating thermogenic adipose tissues (TATs) by cold exposure or β3-adrenergic receptor agonists markedly alleviated development and progression of acute myeloid leukemia and acute lymphoblastic leukemia. The cover portrays a TAT troop clothed in brown (brown adipocytes) assailing a leukemia cell in an icy and snowy milieu. This study indicate that targeting tissues outside of cancer could be an antileukemia therapy. Art by Zhichao Xu.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.