Yan Huang , Ping Hou , Liwei Pan , Jian Li , Xiaoqin Liang , Chenyang Ren , Liuting Peng , Chunqiu Gan , Weifeng Xu , Ruiyun Yang , Jun Li , Xinlan Guan
{"title":"具有潜在抗炎作用的山苍子茎木酚素和酚类物质","authors":"Yan Huang , Ping Hou , Liwei Pan , Jian Li , Xiaoqin Liang , Chenyang Ren , Liuting Peng , Chunqiu Gan , Weifeng Xu , Ruiyun Yang , Jun Li , Xinlan Guan","doi":"10.1016/j.fitote.2024.106253","DOIUrl":null,"url":null,"abstract":"<div><div>Phytochemical investigation of the stems of <em>Mallotus paxii</em> Pamp. led to the isolation and identification of four new compounds, including three neolignans (<strong>1</strong>–<strong>3</strong>) and one phenol (<strong>13</strong>), along with eight known neolignans (<strong>4</strong>–<strong>12</strong>) and one known phenol (<strong>14</strong>). Their structures were determined by spectroscopic methods, including NMR, MS and ECD analyses. Bioassay demonstrated that malloapelin A (<strong>4</strong>) exhibited a most potent anti-inflammatory activity to NO release with IC<sub>50</sub> value of 21.32 μM. Furthermore, malloapelin A (<strong>4</strong>) markedly decreased the secretion of TNF-<em>α</em>, iNOS, and NF-<em>κ</em>B and inhibited the expression of COX-2 and NF-<em>κ</em>B/p65 in LPS-induced RAW264.7 cells in a dose-dependent manner.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106253"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lignans and phenols with potential anti-inflammatory effect from the stems of Mallotus paxii Pamp\",\"authors\":\"Yan Huang , Ping Hou , Liwei Pan , Jian Li , Xiaoqin Liang , Chenyang Ren , Liuting Peng , Chunqiu Gan , Weifeng Xu , Ruiyun Yang , Jun Li , Xinlan Guan\",\"doi\":\"10.1016/j.fitote.2024.106253\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Phytochemical investigation of the stems of <em>Mallotus paxii</em> Pamp. led to the isolation and identification of four new compounds, including three neolignans (<strong>1</strong>–<strong>3</strong>) and one phenol (<strong>13</strong>), along with eight known neolignans (<strong>4</strong>–<strong>12</strong>) and one known phenol (<strong>14</strong>). Their structures were determined by spectroscopic methods, including NMR, MS and ECD analyses. Bioassay demonstrated that malloapelin A (<strong>4</strong>) exhibited a most potent anti-inflammatory activity to NO release with IC<sub>50</sub> value of 21.32 μM. Furthermore, malloapelin A (<strong>4</strong>) markedly decreased the secretion of TNF-<em>α</em>, iNOS, and NF-<em>κ</em>B and inhibited the expression of COX-2 and NF-<em>κ</em>B/p65 in LPS-induced RAW264.7 cells in a dose-dependent manner.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":\"179 \",\"pages\":\"Article 106253\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24004362\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004362","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Lignans and phenols with potential anti-inflammatory effect from the stems of Mallotus paxii Pamp
Phytochemical investigation of the stems of Mallotus paxii Pamp. led to the isolation and identification of four new compounds, including three neolignans (1–3) and one phenol (13), along with eight known neolignans (4–12) and one known phenol (14). Their structures were determined by spectroscopic methods, including NMR, MS and ECD analyses. Bioassay demonstrated that malloapelin A (4) exhibited a most potent anti-inflammatory activity to NO release with IC50 value of 21.32 μM. Furthermore, malloapelin A (4) markedly decreased the secretion of TNF-α, iNOS, and NF-κB and inhibited the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells in a dose-dependent manner.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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