生理学中的昼夜节律调节:对疾病和治疗的影响

IF 7.5 1区 生物学 Q1 CELL BIOLOGY Genes & development Pub Date : 2024-10-17 DOI:10.1101/gad.352180.124
Leonardo Vinicius Monteiro de Assis, Achim Kramer
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引用次数: 0

摘要

时间在生理过程的调节中起着至关重要的作用。如果没有时间控制系统,动物将无法应对周期性的环境变化,从而对其生存产生负面影响。实验研究已经证明,昼夜节律系统在生理过程的时间协调中起着至关重要的作用。将这些研究成果转化到人类身上一直具有挑战性。越来越多的证据表明,饮食、久坐不动、光照和社会时差等现代生活方式因素会对人体昼夜节律系统造成压力,导致失调,即各组织间失去相位一致性。越来越多的证据表明,昼夜节律紊乱会对人体的多项健康指标产生负面影响。本综述旨在全面概述昼夜节律紊乱如何影响各种生理过程、其长期健康后果以及与各种疾病的关联。为了说明昼夜节律紊乱的相关后果,我们重点描述了轮班工人面临的许多生理后果,众所周知,轮班工人的昼夜节律紊乱程度较高。我们还讨论了新兴的昼夜节律医学领域、其基本原则及其对人类健康的潜在影响。
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Circadian de(regulation) in physiology: implications for disease and treatment
Time plays a crucial role in the regulation of physiological processes. Without a temporal control system, animals would be unprepared for cyclic environmental changes, negatively impacting their survival. Experimental studies have demonstrated the essential role of the circadian system in the temporal coordination of physiological processes. Translating these findings to humans has been challenging. Increasing evidence suggests that modern lifestyle factors such as diet, sedentarism, light exposure, and social jet lag can stress the human circadian system, contributing to misalignment; i.e., loss of phase coherence across tissues. An increasing body of evidence supports the negative impact of circadian disruption on several human health parameters. This review aims to provide a comprehensive overview of how circadian disruption influences various physiological processes, its long-term health consequences, and its association with various diseases. To illustrate the relevant consequences of circadian disruption, we focused on describing the many physiological consequences faced by shift workers, a population known to experience high levels of circadian disruption. We also discuss the emerging field of circadian medicine, its founding principles, and its potential impact on human health.
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来源期刊
Genes & development
Genes & development 生物-发育生物学
CiteScore
17.50
自引率
1.90%
发文量
71
审稿时长
3-6 weeks
期刊介绍: Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).
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