Mintu Rehman, D. Sajib, Rasajna Madhusudhana, Rajendar Goreti
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LiTMP-LiBr Complex-Induced Lateral Lithiation and Cross Ester Condensation: Direct Access to Isocoumarins from 2-methoxy o-Toluate Esters
LiTMP-LiBr complex facilitates a novel cross-ester coupling of 2-methoxy o-toluate esters to directly yield isocoumarin without the formation of any carbonyl intermediate is demonstrated. Aggregation plays a pivotal role in driving proximity-induced lateral lithiation, and expediting acylation. Apart from many natural products precursors synthesis of (+)- and (-)-lunatinins is showed.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.