{"title":"LiTMP-LiBr 复合物诱导的侧向锂化和交叉酯缩合：从 2-甲氧基邻甲基苯甲酸酯直接获取异香豆素","authors":"Mintu Rehman , Sajib Daimary , Rasajna Madhusudhana , Rajendar Goreti","doi":"10.1039/d4qo01678e","DOIUrl":null,"url":null,"abstract":"<div><div>A LiTMP-LiBr complex facilitates a novel cross-ester coupling of 2-methoxy <em>o</em>-toluate esters to directly yield isocoumarin without the formation of any carbonyl intermediate. Aggregation plays a pivotal role in driving proximity-induced lateral lithiation and expediting acylation. In addition to many natural product precursors, the synthesis of (+)- and (−)-lunatinins is shown.</div></div>","PeriodicalId":94379,"journal":{"name":"Organic chemistry frontiers : an international journal of organic chemistry","volume":"12 1","pages":"Pages 173-178"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"LiTMP-LiBr complex-induced lateral lithiation and cross ester condensation: direct access to isocoumarins from 2-methoxy o-toluate esters†\",\"authors\":\"Mintu Rehman , Sajib Daimary , Rasajna Madhusudhana , Rajendar Goreti\",\"doi\":\"10.1039/d4qo01678e\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A LiTMP-LiBr complex facilitates a novel cross-ester coupling of 2-methoxy <em>o</em>-toluate esters to directly yield isocoumarin without the formation of any carbonyl intermediate. Aggregation plays a pivotal role in driving proximity-induced lateral lithiation and expediting acylation. In addition to many natural product precursors, the synthesis of (+)- and (−)-lunatinins is shown.</div></div>\",\"PeriodicalId\":94379,\"journal\":{\"name\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"volume\":\"12 1\",\"pages\":\"Pages 173-178\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2052412924007617\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic chemistry frontiers : an international journal of organic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2052412924007617","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/18 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
LiTMP-LiBr complex-induced lateral lithiation and cross ester condensation: direct access to isocoumarins from 2-methoxy o-toluate esters†
A LiTMP-LiBr complex facilitates a novel cross-ester coupling of 2-methoxy o-toluate esters to directly yield isocoumarin without the formation of any carbonyl intermediate. Aggregation plays a pivotal role in driving proximity-induced lateral lithiation and expediting acylation. In addition to many natural product precursors, the synthesis of (+)- and (−)-lunatinins is shown.
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