Magdalena Beran, Willemijn J. Jansen, Julie E. Oomens, Justine E. F. Moonen, P. Eline Slagboom, Martijn Huisman, Almar A. L. Kok, Astrid C. J. Nooyens, Wilhelmina Maria Monique Verschuren, Coen D. A. Stehouwer, Casper Schalkwijk, Sebastian Köhler, Marian Beekman, Pieternella Eline Slagboom, Frank J. Wolters, M. Arfan Ikram, Costanza L. Vallerga, Joyce B. J. van Meurs, Mohsen Ghanbari, Jet M. J. Vonk, Mirjam I. Geerlings, Thomas T. van Sloten, Miranda T. Schram, the NCDC Consortium
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Plasma biomarkers of endothelial dysfunction (soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin) were combined into a standardized composite score. Cognitive outcomes included executive function, processing speed, immediate and delayed memory, attention, and language. Linear regressions and linear mixed models were run in the individual cohorts and standardized coefficients were subsequently pooled using random-effects meta-analyses.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>A higher endothelial dysfunction composite score was cross-sectionally associated with worse performance on executive function, processing speed, delayed memory, and attention, but not immediate memory or language (pooled β-range: −0.04, −0.02). We found no association with change in cognition over time.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>This comprehensive two-step, individual participant data (IPD) meta-analysis showed a small, consistent cross-sectional association between endothelial dysfunction and worse cognitive performance across multiple domains but no support for a longitudinal association.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Prior evidence on endothelial dysfunction (ED) biomarkers and cognition is conflicting.</li>\n \n <li>This two-step, individual participant data (IPD) meta-analysis used data from eight Dutch cohorts.</li>\n \n <li>ED was consistently associated with concurrent cognition.</li>\n \n <li>ED was not associated with a change in cognition over time.</li>\n \n <li>The association of ED with current cognition may be generic.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"20 12","pages":"8402-8411"},"PeriodicalIF":11.1000,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14272","citationCount":"0","resultStr":"{\"title\":\"Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis\",\"authors\":\"Magdalena Beran, Willemijn J. 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Plasma biomarkers of endothelial dysfunction (soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin) were combined into a standardized composite score. Cognitive outcomes included executive function, processing speed, immediate and delayed memory, attention, and language. Linear regressions and linear mixed models were run in the individual cohorts and standardized coefficients were subsequently pooled using random-effects meta-analyses.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>A higher endothelial dysfunction composite score was cross-sectionally associated with worse performance on executive function, processing speed, delayed memory, and attention, but not immediate memory or language (pooled β-range: −0.04, −0.02). 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Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis
INTRODUCTION
This study assessed the association of plasma biomarkers of endothelial dysfunction with cognitive performance and decline.
METHODS
Data from 9414 individuals from eight Dutch cohorts were included (Ø age-range: 57–93 years). Plasma biomarkers of endothelial dysfunction (soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin) were combined into a standardized composite score. Cognitive outcomes included executive function, processing speed, immediate and delayed memory, attention, and language. Linear regressions and linear mixed models were run in the individual cohorts and standardized coefficients were subsequently pooled using random-effects meta-analyses.
RESULTS
A higher endothelial dysfunction composite score was cross-sectionally associated with worse performance on executive function, processing speed, delayed memory, and attention, but not immediate memory or language (pooled β-range: −0.04, −0.02). We found no association with change in cognition over time.
DISCUSSION
This comprehensive two-step, individual participant data (IPD) meta-analysis showed a small, consistent cross-sectional association between endothelial dysfunction and worse cognitive performance across multiple domains but no support for a longitudinal association.
Highlights
Prior evidence on endothelial dysfunction (ED) biomarkers and cognition is conflicting.
This two-step, individual participant data (IPD) meta-analysis used data from eight Dutch cohorts.
ED was consistently associated with concurrent cognition.
ED was not associated with a change in cognition over time.
The association of ED with current cognition may be generic.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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