{"title":"用精氨酸甲基化化学诱导剂将蛋白质定向到溶酶体","authors":"","doi":"10.1038/s41589-024-01744-9","DOIUrl":null,"url":null,"abstract":"Arginine methylation acts as a signal for intracellular proteins to be degraded in lysosomes. We developed methylarginine targeting chimera (MrTAC), a chemical tool that induces proximity with protein arginine N-methyltransferase 1 (PRMT1) to trigger arginine methylation and thus targeted protein degradation in lysosomes.","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"20 12","pages":"1564-1565"},"PeriodicalIF":12.9000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeting proteins to lysosomes with a chemical inducer of arginine methylation\",\"authors\":\"\",\"doi\":\"10.1038/s41589-024-01744-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Arginine methylation acts as a signal for intracellular proteins to be degraded in lysosomes. We developed methylarginine targeting chimera (MrTAC), a chemical tool that induces proximity with protein arginine N-methyltransferase 1 (PRMT1) to trigger arginine methylation and thus targeted protein degradation in lysosomes.\",\"PeriodicalId\":18832,\"journal\":{\"name\":\"Nature chemical biology\",\"volume\":\"20 12\",\"pages\":\"1564-1565\"},\"PeriodicalIF\":12.9000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature chemical biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41589-024-01744-9\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature chemical biology","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41589-024-01744-9","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Targeting proteins to lysosomes with a chemical inducer of arginine methylation
Arginine methylation acts as a signal for intracellular proteins to be degraded in lysosomes. We developed methylarginine targeting chimera (MrTAC), a chemical tool that induces proximity with protein arginine N-methyltransferase 1 (PRMT1) to trigger arginine methylation and thus targeted protein degradation in lysosomes.
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