采用高效薄层色谱法对加标人血浆中的喹硫平、左旋多巴和卡比多巴进行生物分析的绿色度和白度评价

IF 4.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY BMC Chemistry Pub Date : 2024-10-21 DOI:10.1186/s13065-024-01309-w
Finan T. Hindam, Amal M. Abou Al Alamein, Reham M. Arafa, Neven Ahmed, Basma M. Eltanany
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引用次数: 0

摘要

以多巴胺(DOP)为内标,建立了一种可持续的HPTLC-密度测定法,用于定量测定喹硫平(QUET)、左旋多巴(LD)和卡比多巴(CD)。这种适用的技术是通过添加人血浆并采用蛋白沉淀法进行提取实现的。使用的流动相为丙酮、二氯甲烷、正丁醇、冰醋酸和水(体积比为 3:2.5:2:2:1.75)。方法验证根据美国食品药物管理局指南进行,可分别在 100-4000、200-8000 和 30-1300 纳克/毫升范围内定量检测喹硫平、左旋多巴和卡比多巴。对所研究药物的生物分析方法验证参数进行了评估。最后,利用各种绿色和白色分析化学指标及其他工具,如绿色溶剂选择工具、分析生态尺度、绿色分析程序指数、分析绿色度量方法和红-绿-蓝算法工具,对建议的分析方法进行了评估。结果表明,所应用的分析方法对环境的影响较小,与之前报道的其他色谱法相比是一种相对更环保的选择。
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Greenness and whiteness appraisal for bioanalysis of quetiapine, levodopa and carbidopa in spiked human plasma by high performance thin layer chromatography

A sustainable HPTLC-densitometric method was developed for quantitative determination of Quetiapine (QUET), Levodopa (LD) and Carbidopa (CD) in presence of Dopamine (DOP) as an internal standard. This applicable technique was achieved by spiking human plasma and extraction was performed using the protein precipitation approach. The mobile phase used was acetone, dichloromethane, n-butanol, glacial acetic acid and water (3: 2.5: 2: 2: 1.75, by volume). Method validation was done according to US-FDA guidelines and was able to quantify Quetiapine, Levodopa and Carbidopa in the ranges of 100–4000, 200–8000 and 30–1300 ng/mL, respectively. Bioanalytical method validation parameters were assessed for the studied drugs. Finally, the analytical suggested methodology was evaluated using various green and white analytical chemistry metrics and other tools, such as the green solvent selection tool, analytical eco-scale, green analytical procedure index, analytical greenness metric approach and the red–green–blue algorithm tool. The results revealed that the applied analytical method had a minor impact on the environment and is a relatively greener option than other previously reported chromatographic methods.

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来源期刊
BMC Chemistry
BMC Chemistry Chemistry-General Chemistry
CiteScore
5.30
自引率
2.20%
发文量
92
审稿时长
27 weeks
期刊介绍: BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family. Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.
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