{"title":"电分析概述:霉酚酸盐和霉酚酸的传感。","authors":"Robert D. Crapnell and Craig E. Banks","doi":"10.1039/D4AY01379D","DOIUrl":null,"url":null,"abstract":"<p >In this review, we explore the electroanalytical determination of mycophenolate mofetil and mycophenolic acid. Mycophenolate mofetil is a prodrug of mycophenolic acid, which is an immunosuppressive agent used to lower the body's natural immunity in patients who receive organ transplants as well as to treat autoimmune conditions. Laboratory based analytical instrumentation provide a routine methodology to measure mycophenolate mofetil and its metabolites, but there is scope to develop in-the-field analytical measurements that are comparable to those from laboratory equipment. Electroanalysis provides an opportunity to provide highly selective and sensitive outputs but are cost-efficient and can support on-site analysis. In this review, we provide an electroanalytical overview of the current research directed toward the measurement of mycophenolate mofetil and mycophenolic acid, offering insights to future research.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ay/d4ay01379d?page=search","citationCount":"0","resultStr":"{\"title\":\"Electroanalytical overview: the sensing of the mycophenolate mofetil and mycophenolic acid\",\"authors\":\"Robert D. Crapnell and Craig E. Banks\",\"doi\":\"10.1039/D4AY01379D\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >In this review, we explore the electroanalytical determination of mycophenolate mofetil and mycophenolic acid. Mycophenolate mofetil is a prodrug of mycophenolic acid, which is an immunosuppressive agent used to lower the body's natural immunity in patients who receive organ transplants as well as to treat autoimmune conditions. Laboratory based analytical instrumentation provide a routine methodology to measure mycophenolate mofetil and its metabolites, but there is scope to develop in-the-field analytical measurements that are comparable to those from laboratory equipment. Electroanalysis provides an opportunity to provide highly selective and sensitive outputs but are cost-efficient and can support on-site analysis. In this review, we provide an electroanalytical overview of the current research directed toward the measurement of mycophenolate mofetil and mycophenolic acid, offering insights to future research.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2024/ay/d4ay01379d?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/ay/d4ay01379d\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/ay/d4ay01379d","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Electroanalytical overview: the sensing of the mycophenolate mofetil and mycophenolic acid
In this review, we explore the electroanalytical determination of mycophenolate mofetil and mycophenolic acid. Mycophenolate mofetil is a prodrug of mycophenolic acid, which is an immunosuppressive agent used to lower the body's natural immunity in patients who receive organ transplants as well as to treat autoimmune conditions. Laboratory based analytical instrumentation provide a routine methodology to measure mycophenolate mofetil and its metabolites, but there is scope to develop in-the-field analytical measurements that are comparable to those from laboratory equipment. Electroanalysis provides an opportunity to provide highly selective and sensitive outputs but are cost-efficient and can support on-site analysis. In this review, we provide an electroanalytical overview of the current research directed toward the measurement of mycophenolate mofetil and mycophenolic acid, offering insights to future research.