Visible-light-driven catalyst-free C-S cross-coupling of thiol derivatives and aryl halides.

A mild, scalable, and high-yielding visible-light-promoted C-S cross-coupling between alkyl thiol derivatives and (hetero)aryl halides without the need for metals, ligands, or photocatalysts is reported, offering advantages over traditional C-S bond forming strategies. The formation of an electron donor-acceptor (EDA) complex is supported by experimental and computational mechanistic studies, which undergoes visible-light-induced charge transfer to initiate C-S bond formation in the absence of a photoredox catalyst.