多发性远端黄斑病变及其与钙通道阻滞剂的潜在关联:46 名中国患者的回顾性研究。

IF 3.5 4区 医学 Q1 DERMATOLOGY Acta dermato-venereologica Pub Date : 2024-10-10 DOI:10.2340/actadv.v104.40447
Tian Chen, Jia-Wei Liu, Yue-Tong Qian, Xing-Yu Li, Xiao Ma, Jing-Wen Wang, Dong-Lai Ma
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引用次数: 0

摘要

获得性多发性毛细血管扩张症是一种病因不明的获得性皮肤毛细血管扩张症,缺乏有效且经济的治疗方法。本研究旨在找出该病的潜在相关因素,并探索可行的治疗干预措施。在这项回顾性病例系列研究中,共纳入了 46 名在 2007 年 1 月 1 日至 2023 年 5 月 18 日期间确诊为获得性毛细血管扩张症的中国患者。中位发病年龄为43岁(23至60岁),男女比例为10.5:1。除了之前报道的慢性肝病、饮酒和吸烟等相关因素外,研究还发现使用钙通道阻滞剂与获得性多发性毛细血管扩张黄斑病之间存在潜在联系。27 名高血压患者中有 22 人服用了钙通道阻滞剂,其中 17 人接受了随访。停用钙通道阻滞剂后,17 人中有 10 人的病情有不同程度的改善;1 名患者称停用钙通道阻滞剂后病变没有变化;1 名患者继续服药,但在接受 2 次脉冲染料激光治疗后,病情有部分改善;1 名患者观察到病变颜色变浅,但没有改变高血压药物或其他特定治疗方法;另有 4 名患者出于血压稳定的考虑,保留了之前的高血压治疗方案,但病变没有变化。该研究提出,停用钙通道阻滞剂对患者来说是一种新的治疗方法。
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Telangiectasia Macularis Multiplex Acquisita and its Potential Association with Calcium Channel Blockers: A Retrospective Study of 46 Chinese Patients.

Telangiectasia macularis multiplex acquisita is an acquired cutaneous telangiectasis of unknown aetiology, and it lacks both effective and cost-efficient treatment. This study aims to identify a novel potential associated factor of the disease and explore feasible therapeutic interventions. In this retrospective case series study, 46 Chinese patients diagnosed with telangiectasia macularis multiplex acquisita between 1 January 2007 and 18 May 2023 were included. The median age of onset was 43 years (23 to 60 years), and the male to female ratio was 10.5:1. Besides previously reported associations including chronic liver disorders, alcohol consumption, and smoking, a potential association was found between use of calcium channel blockers and development of telangiectasia macularis multiplex acquisita. Twenty-two of 27 hypertensive patients took calcium channel blockers, with 17 followed up. Ten out of 17 displayed a range of improvements following the cessation of calcium channel blockers; 1 patient reported no lesion change post-discontinuation of calcium channel blockers; 1 patient continued their medication but showed partial improvement after 2 pulsed dye laser treatments; 1 patient observed lesion colour lightening without altering hypertensive medication or other specific treatments; and another 4 kept their previous hypertensive regimen due to blood pressure stability concerns, with no change in their lesions. The study proposes that cessation of calcium channel blockers can be a novel therapeutic approach for affected individuals.

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来源期刊
Acta dermato-venereologica
Acta dermato-venereologica 医学-皮肤病学
CiteScore
4.90
自引率
2.80%
发文量
210
审稿时长
6-12 weeks
期刊介绍: Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.
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