体内试验研究:评估脉冲流体冲击动脉瘤壁导致动脉瘤壁膨胀的兔子模型。

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL Annals of Biomedical Engineering Pub Date : 2024-10-22 DOI:10.1007/s10439-024-03633-7
Guillaume Plet, Jolan Raviol, Jean-Baptiste Langlois, Salim Si-Mohamed, Hélène Magoariec, Cyril Pailler-Mattei
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引用次数: 0

摘要

目的:本研究通过评估动脉瘤壁的机械特性,解决了评估未破裂颅内动脉瘤(UIA)破裂风险的关键问题。为此,我们提出了一种基于体内血管壁变形装置原型(DDP)开发的新方法。DDP 的工作原理是将生理液体脉冲注入血管壁,并使用光谱光子计数计算机断层扫描(SPCCT)成像技术测量由此产生的变形:在这项对兔子动物模型进行的初步研究中,先在颈动脉上诱发动脉瘤,然后使用 DDP 对动脉瘤囊壁进行变形。然后对血管壁变形引起的动脉瘤囊腔容积变化进行量化:初步实验结果表明,动脉瘤囊腔容积的增加与 DDP 脉冲流体在动脉壁上流速的增加有关。根据脉动系统施加的不同流速值测量 DDP 产生的压力,发现实验值与动态血压的数量级相同。此外,使用欧拉定理计算的变形区域理论压力值似乎与实验压力测量值相关:理论与实验之间的等效性是使用 DDP 估算血管壁机械特性的关键因素,特别是在使用有限元模型描述变形血管壁的应力状态时。因此,这项初步工作为评估和管理未破裂颅内动脉瘤的破裂风险提供了一种新颖、创新和有前途的方法。
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An In vivo Pilot Study to Estimate the Swelling of the Aneurysm Wall Rabbit Model Generated with Pulsed Fluid Against the Aneurysm Wall.

Purpose: This study addresses the critical issue of evaluating the risk of rupture of unruptured intracranial aneurysms (UIAs) through the assessment of the mechanical properties of the aneurysm wall. To achieve this, an original approach based on the development of an in vivo deformation device prototype (DDP) of the vascular wall is proposed. The DDP operates by pulsing a physiological fluid onto the vascular wall and measuring the resulting deformation using spectral photon counting computed tomography (SPCCT) imaging.

Methods: In this preliminary study conducted on a rabbit animal model, an aneurysm was induced on the carotid artery, followed by deformation of the aneurysm sac wall using the DDP. The change in luminal volume of the aneurysm sac induced by the deformation of the vascular wall was then quantified.

Results: The initial experimental results demonstrated an increase in the luminal volume of the aneurysm sac in relation to the increased flow rate of the fluid pulsed by the DDP onto the arterial wall. Measurement of the pressure generated by the DDP in relation to the different flow rate values imposed by the pulsation system revealed experimental values of the same order of magnitude as dynamic blood pressure. Furthermore, theoretical pressure values on the deformed area, calculated using Euler's theorem, appeared to be correlated with experimental pressure measurements.

Conclusion: This equivalence between theory and experiment is a key element in the use of the DDP for estimating the mechanical properties of the vascular wall, particularly for the use of finite element models to characterise the stress state of the deformed vascular wall. This preliminary work thus presents a novel, innovative, and promising approach for the evaluation and management of the risk of rupture of unruptured intracranial aneurysms.

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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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