以可见光为媒介的 Achmatowicz 重排流动方案。

IF 2.2 4区 化学 Q2 CHEMISTRY, ORGANIC Beilstein Journal of Organic Chemistry Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.213
Joachyutharayalu Oja, Sanjeev Kumar, Srihari Pabbaraja
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引用次数: 0

摘要

原料药/药物合成的批量工艺容易受到很大的限制,包括工艺时间较长、技术人员短缺、合成后工作繁琐等。为了解决批量工艺固有的局限性,我们采用了一种新方法,建立并开发了一种可见光辅助模块化光流反应器,该反应器具有无缝集成的合成后处理程序,能够从糠醇高效合成二氢吡喃酮。该反应使用太阳光作为绿色能源,开发的新型光流反应器平台与集成系统相结合,能够以省时省力的方式进行下游处理,促进 Achmatowicz 重排,从而快速(10 分钟)形成二氢吡喃酮产品。
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Visible-light-mediated flow protocol for Achmatowicz rearrangement.

The batch processes of APIs/pharmaceutical synthesis are prone to suffer significant limitations, including longer process time, shortage of skilled manpower, laborious post-synthetic work-up, etc. To address the inherent limitations of batch processes, a novel approach was undertaken, resulting in the establishment and development of a visible light-assisted modular photo-flow reactor with a seamlessly integrated post-synthetic work-up procedure enabling the efficient synthesis of dihydropyranones from furfuryl alcohols. The reaction uses sun light as green energy source, and the novel photo-flow reactor platform developed with an integrated system enabling a downstream process in a time and labor-efficient manner which facilitates the Achmatowicz rearrangement, resulting in a fast (10 min) formation of the dihydropyranone products.

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来源期刊
CiteScore
4.90
自引率
3.70%
发文量
167
审稿时长
1.4 months
期刊介绍: The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.
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