骨坏死:光生物调节和光动力疗法--系统综述。

IF 2 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI:10.1136/spcare-2024-004874
Rodrigo Antico Benetti, Gabriela Biihrer Belei, Rafael Pecoraro-Andrade, Priscila Benitz Rios de Oliveira, Tânia Barbosa Dos Santos, Rodrigo Labat Marcos, Adriana Lino-Dos-Santos-Franco, Maria Fernanda Setúbal Destro Rodrigues, Linamara Rizzo Battistella, Rebeca Boltes Cecatto
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引用次数: 0

摘要

目前已研究出多种治疗骨坏死的辅助疗法。光生物调节和光动力疗法是常用的治疗方法。为了评估光生物调节和光动力疗法在治疗与用药有关或与电离辐射有关的骨坏死方面的效果,我们进行了一项系统综述和Meta分析的首选报告项目。在检索了PubMed、EMBASE、LILACS和Livivo数据库后,筛选出了2篇系统综述、4篇前瞻性比较研究、10篇比较研究和23篇回顾性病例报告。研究发现,光生物调节疗法在缓解疼痛和治愈因服用抗骨质吸收药物导致的颌骨坏死方面取得了积极成果。关于光动力疗法和骨坏死的研究有限。没有关于不良反应的报道。尽管证据质量不高,但研究结果表明,光生物调节疗法可作为骨质疏松症患者的辅助疗法,尤其是那些不符合手术条件的患者。对肿瘤患者也有类似的益处,但缺乏评估癌症相关结果的对照试验,因此需要进一步研究。
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Osteonecrosis: photobiomodulation and photodynamic therapy - a systematic review.

A wide range of adjuvant treatments have been studied to treat osteonecrosis. Photobiomodulation and photodynamic therapy are commonly used. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review was conducted to evaluate photobiomodulation and photodynamic therapy for the treatment of osteonecrosis related to the use of medications or related to ionising radiation. After searching PubMed, EMBASE, LILACS and Livivo Database, 2 systematic reviews, 4 prospective comparative studies, 10 comparative studies and 23 retrospective case reports were selected. Photobiomodulation-positive outcomes were observed in pain management and healing linked to osteonecrosis of the jaw due to antiresorptive drugs. Limited studies exist on photodynamic therapy and osteoradionecrosis. No adverse effects were reported. Despite the low quality of evidence, findings suggest that photobiomodulation may serve as an adjuvant therapy for osteoporotic patients, particularly those ineligible for surgery. Similar benefits were noted for oncological patients, but controlled trials evaluating cancer-related outcomes are lacking, emphasising the need for further research.

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来源期刊
BMJ Supportive & Palliative Care
BMJ Supportive & Palliative Care Medicine-Medicine (miscellaneous)
CiteScore
4.60
自引率
7.40%
发文量
170
期刊介绍: Published quarterly in print and continuously online, BMJ Supportive & Palliative Care aims to connect many disciplines and specialties throughout the world by providing high quality, clinically relevant research, reviews, comment, information and news of international importance. We hold an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, epidemiology, behavioural sciences, ethics and health service research. Articles with relevance to clinical practice and clinical service development will be considered for publication. In an international context, many different categories of clinician and healthcare workers do clinical work associated with palliative medicine, specialist or generalist palliative care, supportive care, psychosocial-oncology and end of life care. We wish to engage many specialties, not only those traditionally associated with supportive and palliative care. We hope to extend the readership to doctors, nurses, other healthcare workers and researchers in medical and surgical specialties, including but not limited to cardiology, gastroenterology, geriatrics, neurology, oncology, paediatrics, primary care, psychiatry, psychology, renal medicine, respiratory medicine.
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