子痫前期发病机制中的氧化氮（NO）。

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Bulletin of Experimental Biology and Medicine Pub Date : 2024-10-01 Epub Date: 2024-10-22 DOI:10.1007/s10517-024-06255-0

V Yu Titov, A N Osipov, I V Babenkova, Yu O Teselkin, R I Shalina, Yu V Vykhristyuk, S Yu Lebedeva

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引用次数: 0

摘要

子痫前期孕妇血浆中一氧化氮（NO）供体的浓度是健康孕妇的数倍。非通过一氧化氮介导机制发挥作用的降压药可使一些子痫前期妇女的血压恢复正常，但并不能显著降低血浆中一氧化氮供体的水平。看来，子痫前期与靶点的 NO 供应不足有关，而不是与 NO 合成强度低有关。因此，血浆中 NO 供体分子的浓度可以作为子痫前期的一个有用的额外诊断指标。

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Nitrogen Oxide (NO) in the Pathogenesis of Preeclampsia.

The concentrations of nitric oxide (NO) donors in the plasma of pregnant women with preeclampsia is several times higher than in healthy pregnant women. Antihypertensive drugs acting not through the NO-mediated mechanisms normalized BP in some women with preeclampsia, but did not significantly reduce the levels of NO donors in the plasma. It appears that preeclampsia is associated with insufficient NO availability for the targets, rather than low intensity of NO synthesis. The concentration of NO donor molecules in the plasma can therefore be a useful additional diagnostic marker of preeclampsia.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.