朗格汉斯细胞的缺失导致中性粒细胞过度流入,增加了皮肤伤口的细菌负担。

IF 8.1 1区 生物学 Q1 CELL BIOLOGY Cell Death & Disease Pub Date : 2024-10-19 DOI:10.1038/s41419-024-07143-1
Zheng-Cai Wang, Yan-Yan Hu, Xiao Z Shen, Wei-Qiang Tan
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引用次数: 0

摘要

朗格汉斯细胞(Langerhans cells,LCs)是表皮中的常驻树突状细胞,它们在呈现来自皮肤中微生物的抗原方面的作用已得到广泛认可。然而,一般认为中性粒细胞主要负责在伤口早期消灭入侵的病原体,而 LCs 在先天性免疫中的作用尚不明确。在本研究中,我们发现缺乏 LCs 的伤口会延迟闭合。从机制上讲,LCs 是伤口愈合早期抵御细菌入侵的主要细胞。如果没有 LCs,共生细菌就会迅速入侵并在伤口区域繁殖。伤口周围的角质细胞会通过增加 CXCL5 的分泌来应对过多的细菌,从而导致中性粒细胞的过度涌入。活化的中性粒细胞的过度存在,可能加上细菌入侵的加剧,不利于表皮祖细胞的繁殖和再上皮化。这些观察结果突显了 LCs 作为有效的守护者所发挥的不可或缺的作用,它既能阻止细菌入侵,又能防止继发性炎症造成的损害。
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Absence of Langerhans cells resulted in over-influx of neutrophils and increased bacterial burden in skin wounds.

Langerhans cells (LCs) are resident dendritic cells in the epidermis and their roles in presenting antigens derived from microorganisms present in the skin has been well appreciated. However, it is generally thought that incoming neutrophils are mainly responsible for eradicating invading pathogens in the early stage of wounds and a role of LCs in innate immunity is elusive. In the current study, we showed that wounds absent of LCs had a delayed closure. Mechanistically, LCs were the primary cells in warding off bacteria invasion at the early stage of wound healing. Without LCs, commensal bacteria quickly invaded and propagated in the wounded area. keratinocytes surrounding the wounds responded to the excessive bacteria by elevated production of CXCL5, resulting in an over-influx of neutrophils. The over-presence of activated neutrophils, possibly together with the aggravated invasion of bacteria, was detrimental to epidermal progenitor cell propagation and re-epithelialization. These observations underscore an indispensable role of LCs as effective guardians that preclude both bacteria invasion and damages inflicted by secondary inflammation.

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来源期刊
Cell Death & Disease
Cell Death & Disease CELL BIOLOGY-
CiteScore
15.10
自引率
2.20%
发文量
935
审稿时长
2 months
期刊介绍: Brought to readers by the editorial team of Cell Death & Differentiation, Cell Death & Disease is an online peer-reviewed journal specializing in translational cell death research. It covers a wide range of topics in experimental and internal medicine, including cancer, immunity, neuroscience, and now cancer metabolism. Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following: Experimental medicine Cancer Immunity Internal medicine Neuroscience Cancer metabolism
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