肼和肼衍生物：特性、应用和重新定位的潜力。

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2024-10-21 DOI:10.1002/cbdv.202401561

Ivana Carneiro Romão, Sônia Maria Costa Siqueira, Flávia Oliveira Monteiro da Silva Abreu, Hélcio Silva Dos Santos

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引用次数: 0

摘要

研究新药既缓慢又昂贵。药物的重新定位（如老式降压药 Hydralazine (HDZ)）可以加快这一进程。HDZ 及其肼基衍生物具有多种生物活性，有望成为新药。本综述探讨了 HDZ 的重新定位潜力及其衍生物在各种生物活性中的应用。通过数据库搜索，共找到 70 篇相关文章。HDZ 在神经病学、肿瘤学、肾病学和妇科方面显示出潜力，临床试验已进入第三阶段。在墨西哥上市的丙戊酸肼在与化疗结合使用时效果显著。肼基衍生物在医学领域有着广泛的应用。研究它们的结构-活性关系可以提高疗效。本综述简明扼要地总结了它们的特性和药理活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hydralazine and Hydrazine Derivatives: Properties, Applications, and Repositioning Potential.

The investigation of new drugs is slow and costly. Drug repositioning, like with Hydralazine (HDZ), an old antihypertensive, can accelerate the process. HDZ and its hydrazonic derivatives exhibit diverse biological activities, promising for new drugs. This review explores HDZ's repositioning potential and its derivatives' applications in various biological activities. It identified 70 relevant articles through database searches. HDZ shows potential in neurology, oncology, nephrology, and gynecology, with clinical trials up to Phase III. Hydralazine-valproate, marketed in Mexico, proves effective in combination with chemotherapy. Hydrazonic derivatives offer broad applications in medicine. Studying their structure-activity relationship can enhance efficacy. This review summarizes their properties and pharmacological activities succinctly.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.