小胶质细胞中的糖酵解重编程：缺血性中风的潜在治疗靶点

IF 4.4 2区生物学 Q2 CELL BIOLOGY Cellular signalling Pub Date : 2024-10-15 DOI:10.1016/j.cellsig.2024.111466

Guangming Zhang , Anliu Zhao , Xiaolu Zhang , Miao Zeng , Huayuan Wei , Xu Yan , Jie Wang , Xijuan Jiang , Yongna Dai

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引用次数: 0

摘要

缺血性中风是目前全球第二大死亡原因，但可供选择的治疗方法却很有限。作为常驻免疫细胞，小胶质细胞会对脑缺血损伤做出迅速反应，影响神经炎症损伤和神经修复。研究表明，小胶质细胞在缺血时会发生新陈代谢重编程，从线粒体氧化磷酸化转变为糖酵解，从而显著影响其在缺血性卒中期间的功能。因此，本研究旨在探讨这一过程中的作用和调控机制，从而确定新的治疗靶点或潜在候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Glycolytic reprogramming in microglia: A potential therapeutic target for ischemic stroke

Ischemic stroke is currently the second leading cause of mortality worldwide, with limited treatment options available. As resident immune cells, microglia promptly respond to cerebral ischemic injury, influencing neuroinflammatory damage and neurorepair. Studies suggest that microglia undergo metabolic reprogramming from mitochondrial oxidative phosphorylation to glycolysis in response to ischemia, significantly impacting their function during ischemic stroke. Therefore, this study aims to investigate the roles and regulatory mechanisms involved in this process, aiming to identify a new therapeutic target or potential drug candidate.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.