贝赫切特综合征的甲沟视网膜镜检查异常和血管表现。

IF 3.4 4区 医学 Q2 RHEUMATOLOGY Clinical and experimental rheumatology Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI:10.55563/clinexprheumatol/v5mz8d
Joan Maria Mercadé-Torras, Alfredo Guillén-Del-Castillo, Segundo Buján, Roser Solans-Laque
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引用次数: 0

摘要

目的:评估 BS 患者的微循环异常及其临床关联:评估BS患者的微循环异常及其临床关联,尤其是有血管表现的患者:方法:采用甲襞视频显像镜(NVC)对 BS 患者的微循环进行横断面研究:结果:共有 65 名患者参与研究。34例(52.3%)为男性,84.6%为欧洲白种人。24名患者(36.9%)出现血管受累。在 47.7% 的患者中观察到 NVC 定性异常。最常见的是毛细血管迂曲和分支(21.5%),其次是微出血(12.3%)、毛细血管扩大(7.7%)和巨大毛细血管(3.1%)。我们发现,毛细血管迂曲和分支的存在与既往浅表血栓性静脉炎(ST)有明显关系(P=0.025)。NVC 中出现≥2 个定性异常与血管受累有关(p=0.031),主要与静脉血栓事件有关(p=0.024),尤其与 ST 有关(p=0.003)。未观察到特定的 Cutolo 模式。尽管 ANA 阳性的患者出现非特异性毛细血管镜异常的频率更高(p=0.003),但未观察到 NVC 与雷诺现象或 ANA 之间的关联:结论:NVC中出现≥2个定性异常与血管-贝赫切特相关。NVC可能是早期发现有血管事件风险的患者的潜在工具。
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Nailfold videocapillaroscopy abnormalities and vascular manifestations in Behçet's syndrome.

Objectives: To evaluate microcirculation abnormalities and their clinical association in patients with BS, especially with vascular manifestations.

Methods: A cross-sectional study was carried out using nailfold videocapillaroscopy (NVC) to evaluate the microcirculation in patients with BS.

Results: A total of 65 patients were included in the study. Thirty-four (52.3%) were men, and 84.6% were European Caucasian. Vascular involvement was present in 24 (36.9%) patients. Qualitative abnormalities in NVC were observed in 47.7% of patients. The most frequent were tortuous and branched capillaries (21.5%), followed by microhaemorrhage (12.3%), enlarged capillary (7.7%) and giant capillary (3.1%). We found a significant relationship between the presence of tortuous and branched capillaries and previous superficial thrombophlebitis (ST) (p=0.025). The presence of ≥2 qualitative abnormalities in NVC was associated with vascular involvement (p=0.031), mainly with venous thrombotic events (p=0.024) and particularly with ST (p=0.003). No specific Cutolo's pattern was observed. No association was observed between NVC and Raynaud's phenomenon or ANA, although patients with positive ANA presented more frequent non-specific capillaroscopic abnormalities (p=0.003).

Conclusions: The presence of ≥2 qualitative abnormalities in NVC is associated with Vasculo-Behçet. NVC might be a potential tool for early detection of patients at risk of vascular events.

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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
期刊最新文献
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