发现濒临灭绝的北美草本植物 Actaea racemosa 的未开发前景。

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS Combinatorial chemistry & high throughput screening Pub Date : 2024-10-11 DOI:10.2174/0113862073309185240923053809
Genevive Kharumnuid, Rashmi Saxena Pal, Yogendra Pal, Motamarri Naga Lalitha Chaitanya, Preeti Srivastava
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摘要

Actaea racemosa(AR)有时也被称为黑升麻,是一种生长在毛茛科的多年生草本植物,在盛夏开花。这种草本植物目前遍布北美南部和西部,尽管在北美大陆东部已濒临灭绝。关于这种草本植物的光化学和生物潜力,目前已有一定的资料。根据现有的少量民族医学报告,这种草药具有抗氧化、抗糖尿病、抗炎、抗骨质疏松症和抗癌特性。根据现有文献,咖啡酸、异阿魏酸、猕猴桃苷、23-epi-26 deoxycatein、升麻苷和阿魏酸是 AR 不同部位的主要成分。迄今为止,还没有深入研究或系统综述来强调这种草药的传统、生物和植物化学功效。因此,需要进行进一步的研究,以加深对这种治疗性草药的了解,特别是对其绝缘部分的分离和药理筛选,以了解其一系列生物功能。本综述旨在汇编 AR.植物化学成分的最新数据,这些数据与 AR.的民族医药应用、提取方法、药理应用和未来潜力有关。
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Discovering the Untouched Perspective of Endangered North American Herb Actaea racemosa.

Actaea racemosa (AR), sometimes also known as black cohosh, is a perennial herb that grows in the Ranunculaceae family that effloresces in the middle of summer. This herb is currently present throughout south and west North America despite being endangered in the eastern section of the continent. Certain information about the photochemistry and biological potential of this herb is available. In accordance with the scant available ethno-medical reports, this herb possesses antioxidant, antidiabetic, anti-inflammatory, antiosteoporosis, and anticancer properties. As per the available literature, caffeic acid, isoferulic acid, actein, 23-epi-26 deoxycatein, cimicifugoside, and ferukinolic acid are the key components found in different parts of AR. To date, no thorough research or systematic review has been done to highlight the traditional, biological, and phytochemical benefits of this herb. Consequently, further research is needed to gain a deeper understanding of this therapeutic herb, particularly about its separation and pharmacological screening of its insulating portion for a range of biological functions. The goal of this review was to compile the most recent data on the phytochemical presence of AR. in relation to its ethnomedical applications, methods of extraction, pharmacological applications, and future potential.

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来源期刊
CiteScore
3.10
自引率
5.60%
发文量
327
审稿时长
7.5 months
期刊介绍: Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.
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