气管移植:可用于肺移植的经验教训。

IF 1.8 4区 医学 Q3 TRANSPLANTATION Current Opinion in Organ Transplantation Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI:10.1097/MOT.0000000000001180
Eric M Genden, Ya-Wen Chen
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引用次数: 0

摘要

综述目的:本综述旨在探讨从实验和人体气管移植中吸取的经验教训,以确定这些信息是否可应用于肺移植:动物模型的实验工作和最近的人体气管移植表明,强大的气管血管供应可预防吻合并发症。此外,这项工作还表明,随着受体上皮细胞重新填充异体移植物,气管异体移植物会逐渐发生嵌合。与大多数血管化复合异体移植物(如手部和面部移植)的高排斥率不同,气管异体移植物没有出现排斥反应。小结:吻合口并发症和慢性异体移植排斥反应是肺移植最常见的并发症,而气管移植的相关研究结果可能对减少肺移植并发症有一定意义。
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Tracheal transplantation: lessons learned that may apply to lung transplantation.

Purpose of review: The purpose of this review is to explore the lessons learned from experimental and human tracheal transplantation to determine if this information may be applied to lung transplantation.

Recent findings: Experimental work in animal models and the recent human tracheal transplantation suggests that a robust tracheal vascular supply prevents anastomotic complications. Further, this work demonstrates that tracheal allografts undergo a progressive chimerism as recipient epithelium repopulates the allograft. In contrast to most vascularized composite allografts such as hand and face transplantation that experience high rates of rejection, the tracheal allograft did not demonstrate rejection. This may suggest that tissue chimerism plays a role in evading immune-mediated allograft rejection.

Summary: While anastomotic complications and chronic allograft rejection are the most common complications related to lung transplantation, the findings associated with tracheal transplantation may have implications for both reducing complications associated with lung transplantation.

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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
期刊最新文献
Ethical considerations in lung re-transplantation. Ethics of abortion in transplantation. Establishing an upper extremity transplantation program: lessons learnt over 12 years. The current state of tolerance induction in vascularized composite allotransplantation. Tracheal transplantation: lessons learned that may apply to lung transplantation.
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