对用于抗菌治疗的脂质体纳米疗法的深入了解。

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2024-10-17 DOI:10.2174/0109298673322058241003073312
Kiran Jani, Swapnil Mehta, Riya Patel, Bhupendra Prajapati, Gayatri Patel
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引用次数: 0

摘要

应对传染性疾病是一项艰巨的挑战,这主要是由于细菌耐药性问题不断升级。再加上有限的财政资源和停滞不前的抗生素研究,加剧了抗生素危机。创新战略,包括新型抗生素开发和替代解决方案,对于抗击微生物耐药性至关重要。纳米疗法为增强药物输送系统提供了一种前景广阔的方法。与基于脂质的纳米级给药系统相结合,特别是通过将治疗物质封装在脂质体载体中,可显著延长药物在感染部位的存在时间。这不仅能降低毒性,还能防止抗生素降解。脂质载体,尤其是脂质体,在靶向感染细胞方面具有显著的特异性。这为抗菌药耐药性的防治带来了巨大希望,并有可能改变多重耐药感染的治疗方法。利用脂质体载体可能会在解决耐药细菌感染方面取得突破性进展。本综述强调了负载抗菌药物的脂质体作为一种新型给药系统治疗细菌感染的潜力。在脂质体中封装抗菌剂可提高治疗效率。此外,脂质体系统还能应对抗菌药耐药性带来的挑战,为控制持续性多重耐药感染带来希望。在抗击细菌耐药性和抗生素危机的斗争中,使用抗菌药脂质体作为给药载体大有可为。这种创新方法不仅能延长药效、降低毒性,还能为解决高度耐药的感染性疾病提供一条途径。随着研究的深入,脂质体纳米疗法可能成为抗击细菌感染的变革性解决方案。
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Focused Insights into Liposomal Nanotherapeutics for Antimicrobial Treatment.

Addressing infectious conditions presents a formidable challenge, primarily due to the escalating issue of bacterial resistance. This, coupled with limited financial resources and stagnant antibiotic research, compounds the antibiotic crisis. Innovative strategies, including novel antibiotic development and alternative solutions, are crucial to combat microbial resistance. Nanotherapeutics offers a promising approach to enhance drug delivery systems. Integration into lipid-based nanoscale delivery systems, particularly through therapeutic substance encapsulation in liposomal carriers, significantly prolongs drug presence at infection sites. This not only reduces toxicity but also shields antibiotics from degradation. Lipidic carriers, particularly liposomes, exhibit remarkable specificity in targeting infectious cells. This holds great promise in combating antimicrobial resistance and potentially transforming treatment for multi-drug resistant infections. Leveraging liposomal carriers may lead to breakthroughs in addressing drugresistant bacterial infections. This review emphasizes the potential of antimicrobial-loaded liposomes as a novel delivery system for bacterial infections. Encapsulating antimicrobial agents within liposomes enhances treatment efficiency. Moreover, liposomal systems counteract challenges posed by antimicrobial resistance, offering hope in managing persistent multidrug-resistant infections. In the battle against bacterial resistance and the antibiotics crisis, the use of antimicrobial-loaded liposomes as delivery vehicles shows great promise. This innovative approach not only extends drug effectiveness and reduces toxicity but also provides a path to address highly resistant infectious conditions. As research advances, liposomal nanotherapeutics may emerge as a transformative solution in the fight against bacterial infections.

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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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