BDNF在电休克疗法抗抑郁效果中的作用

Q3 Agricultural and Biological Sciences Doklady Biological Sciences Pub Date : 2024-10-11 DOI:10.1134/S0012496624600313

V M Ushakova, E A Zubkov, A Yu Morozova, K A Pavlov, Ya A Zorkina, O V Abramova, A G Ochneva, O I Gurina, K Sh Tarkovskaya, A N Inozemtsev, V P Chekhonin

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引用次数: 0

摘要

电休克疗法（ECT）是治疗抑郁症的一种有效方法。它能产生多种生物效应，包括神经营养因子调节。本文研究了抑郁症大鼠在接受变频超声（20-45 kHz）治疗后的电休克反应，并考察了脑源性神经营养因子（BDNF）表达变化对所观察到的效果的贡献。所得结果反映了 ECT 治疗啮齿类动物抑郁样状态的潜力，并表明 BDNF 在这些过程中的作用。在未来的研究中，有必要调查神经营养素和结构变化之间的关系，并研究可能与抑郁样状态的发展和治疗反应相关的其他神经营养生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of BDNF in the Antidepressant Effects of Electroconvulsive Therapy.

Electroconvulsive therapy (ECT) is an effective treatment method for depression therapy. It produces a number of biological effects, including neurotrophic factors regulation. In the present paper, we investigated the ECT response in depressed rats subjected to the variable frequency ultrasound (20-45 kHz) and examined the contribution of brain-derived neurotrophic factor (BDNF) expression changes to the observed effects. The obtained results reflect the therapeutic potential of ECT for the treatment of depressive-like state in rodents and indicate the role of BDNF in these processes. In future research, it is necessary to investigate the relationship between neurotrophin and structural changes and to study other neurotrophic biomarkers that may be associated with the development of depression-like state and the therapy response.

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来源期刊

Doklady Biological Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

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期刊介绍： Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.