整合昼夜节律和免疫疗法,提高脑癌治疗的精准度。

IF 9.7 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL EBioMedicine Pub Date : 2024-10-15 DOI:10.1016/j.ebiom.2024.105395
Matthias Quist, Maas van Os, Linda W van Laake, Niels Bovenschen, Sandra Crnko
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引用次数: 0

摘要

昼夜节律对(病理)生理过程有重大影响,其紊乱与神经退行性疾病和癌症易感性增加有关。虽然免疫疗法在治疗各种癌症方面前景看好,但其在脑部恶性肿瘤中的疗效仍然有限。这篇综述探讨了脑癌治疗中昼夜节律与免疫疗法的关系,强调通过与人体内部时钟保持一致来实现精准治疗。我们评估了免疫反应的昼夜节律调节,包括细胞定位和功能表型,并讨论了昼夜节律失调如何影响抗癌免疫。此外,我们还分析和评估了当前脑癌免疫治疗方法的有效性,包括免疫检查点阻断、采纳性细胞疗法和其他新型策略。我们还提出了未来的发展方向,如时间疗法和个性化治疗计划,以优化针对脑癌的精准免疫疗法。总之,这篇综述让人们了解了昼夜节律在脑癌中经常被忽视的作用,并提出了改善免疫治疗效果的途径。
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Integration of circadian rhythms and immunotherapy for enhanced precision in brain cancer treatment.

Circadian rhythms significantly impact (patho)physiological processes, with disruptions linked to neurodegenerative diseases and heightened cancer vulnerability. While immunotherapy has shown promise in treating various cancers, its efficacy in brain malignancies remains limited. This review explores the nexus of circadian rhythms and immunotherapy in brain cancer treatment, emphasising precision through alignment with the body's internal clock. We evaluate circadian regulation of immune responses, including cell localisation and functional phenotype, and discuss how circadian dysregulation affects anti-cancer immunity. Additionally, we analyse and assess the effectiveness of current immunotherapeutic approaches for brain cancer including immune checkpoint blockades, adoptive cellular therapies, and other novel strategies. Future directions, such as chronotherapy and personalised treatment schedules, are proposed to optimise immunotherapy precision against brain cancers. Overall, this review provides an understanding of the often-overlooked role of circadian rhythms in brain cancer and suggests avenues for improving immunotherapeutic outcomes.

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来源期刊
EBioMedicine
EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍: eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.
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