甲状腺激素介导的选择性自噬及其在对抗代谢功能障碍相关性脂肪肝中的意义

IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-10-14 DOI:10.3803/EnM.2024.2068
Rohit A Sinha
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引用次数: 0

摘要

甲状腺激素(TH)对肝脏代谢的影响引起了药理学家的关注,他们正在寻找治疗代谢功能障碍相关性脂肪性肝病(MASLD)的新方法,这是一种越来越常见的代谢性疾病。在这种情况下,临床前模型中 TH 对自噬的选择性诱导被认为是一种很有前景的机制。在这一过程中,TH 通过脂肪吞噬清除肝内脂肪,同时通过有丝分裂保护肝细胞免受炎症和线粒体损伤。此外,TH 诱导的自噬可能是一种保护机制,可减轻 MASLD 相关肝细胞癌的发展。考虑到在人类 MASLD 进展过程中观察到的自噬缺陷,TH、其代谢物及其类似物诱导自噬是对抗整个 MASLD 肝损伤的一种新策略。
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Thyroid Hormone-Mediated Selective Autophagy and Its Implications in Countering Metabolic Dysfunction-Associated Steatotic Liver Disease.

The influence of thyroid hormone (TH) on liver metabolism has attracted the attention of pharmacologists seeking new treatments for metabolic dysfunction-associated steatotic liver disease (MASLD), an increasingly common metabolic disorder. In this context, the selective induction of autophagy by TH in preclinical models has been identified as a promising mechanism. In this process, TH clears intrahepatic fat through lipophagy while protecting against inflammation and mitochondrial damage in hepatocytes via mitophagy. Furthermore, TH-induced aggrephagy may represent a protective mechanism to mitigate the development of MASLD-associated hepatocellular carcinoma. Considering the defects in autophagy observed during the progression of human MASLD, the induction of autophagy by TH, its metabolites, and its analogs represent a novel strategy to combat hepatic damage across the MASLD spectrum.

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来源期刊
Endocrinology and Metabolism
Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.60
自引率
5.90%
发文量
145
审稿时长
24 weeks
期刊介绍: The aim of this journal is to set high standards of medical care by providing a forum for discussion for basic, clinical, and translational researchers and clinicians on new findings in the fields of endocrinology and metabolism. Endocrinology and Metabolism reports new findings and developments in all aspects of endocrinology and metabolism. The topics covered by this journal include bone and mineral metabolism, cytokines, developmental endocrinology, diagnostic endocrinology, endocrine research, dyslipidemia, endocrine regulation, genetic endocrinology, growth factors, hormone receptors, hormone action and regulation, management of endocrine diseases, clinical trials, epidemiology, molecular endocrinology, neuroendocrinology, neuropeptides, neurotransmitters, obesity, pediatric endocrinology, reproductive endocrinology, signal transduction, the anatomy and physiology of endocrine organs (i.e., the pituitary, thyroid, parathyroid, and adrenal glands, and the gonads), and endocrine diseases (diabetes, nutrition, osteoporosis, etc.).
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