儿童中的暴力色杆菌感染:两例病例报告和文献综述。

IF 3.7 3区 医学 Q2 INFECTIOUS DISEASES European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2024-12-01 Epub Date: 2024-10-17 DOI:10.1007/s10096-024-04949-x
ZhiHong Jiang, YiFan Ren, Sheng Ye
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引用次数: 0

摘要

目的:暴力铬杆菌(C. violaceum)是一种革兰氏阴性细菌,很少感染人类,尤其是儿童。然而,该病的死亡率很高,而且没有明确的治疗指南。本文旨在提高临床医生对儿童感染暴力杆菌引起的疾病的认识,及时诊断和治疗,提高患者存活率,降低死亡率:我们分析了过去 10 年中与儿科相关的最新英文文献,总结了最新的损伤机制、易感因素、不良预后和死亡率预测因素、死亡率、降低死亡率的方法、临床表现、新诊断方法、治疗药物以及针对暴牙弧菌的未来药物开发方向:根据现有数据,我们得出结论:当儿童出现蜂窝组织炎、败血症和内脏脓肿并伴有皮肤损伤和接触积水或土壤的病史时,应考虑并诊断是否感染了暴马蜂毒素。当临床医生强烈怀疑儿童感染了这种细菌时,如果儿童病情严重,建议使用环丙沙星。如果患儿病情不严重,可以选择对儿童副作用相对较小的药物,如庆大霉素、三甲双氨/磺胺甲噁唑、亚胺培南等药物。获得药敏结果后,医生可根据抗菌谱调整抗菌治疗方案。
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Chromobacterium violaceum infections in children: two case reports and literature review.

Purpose: Chromobacterium violaceum(C. violaceum) is a gram-negative bacterium that rarely infects humans, especially children. However, the mortality rate is high and there are no clear guidelines for treatment. The aim of this paper is to increase clinicians' awareness of diseases caused by C. violaceum infections in children, to diagnose and treat them in a timely manner, to improve patient survival and to reduce mortality.

Results: We analysed the latest paediatric-related English language literature over the last 10 years and summarised the latest mechanisms of injury, susceptibility factors, adverse prognostic and mortality predictors, mortality rates, methods to reduce mortality, clinical manifestations, new diagnostic methods, therapeutic agents and directions for future drug development for C. violaceum.

Conclusions: Based on the available data, we conclude that the possibility of C. violaceum infection should be considered and diagnosed when cellulitis, septicaemia and visceral abscesses develop in children with a history of skin injury and exposure to stagnant water or soil. When clinicians strongly suspect that a child is infected with this bacterium, the recommended medication is ciprofloxacin if the child presents with severe illness. If the child has a non-severe condition, medications with relatively fewer side effects for children can be chosen, such as gentamicin, trimethoprim/ sulfamethoxazole, imipenem, and other drugs. The physician can then adjust the antimicrobial regimen based on the antimicrobial spectrum after obtaining the drug sensitivity results.

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来源期刊
CiteScore
10.40
自引率
2.20%
发文量
138
审稿时长
1 months
期刊介绍: EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.
期刊最新文献
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