对身材矮小的女性进行磁共振骨盆测量以确定头盆不称风险的可行性研究。

IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2024-10-10 DOI:10.1016/j.ejogrb.2024.10.001
Amin Z , Wilson C , Offiah I , Puckett M , Musicha C , Dua A , Freeman R
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引用次数: 0

摘要

目的进行一项可行性研究,评估是否可以对身材矮小的初产妇进行磁共振骨盆测量,以期开展一项主要研究,回答 "磁共振骨盆测量能否用于预测身材矮小妇女的头盆不称(CPD)"这一问题:研究设计:这是一项前瞻性单臂可行性研究。研究设计:这是一项前瞻性单臂可行性研究。第一阶段,患者和公众参与评估研究的可接受性。第二阶段,从产前门诊中挑选身高≤160厘米的初产妇。产科医生和助产士被要求向所有符合条件的妇女介绍这项研究。在怀孕三个月时接触患者,并提供有关该研究的书面信息。如果患者同意参与,则会邀请她们签署同意书。磁共振扫描从妊娠 36 周开始进行。直到分娩后,患者及其产科医生才会被告知磁共振扫描的结果(考虑到 NICE 和 WHO 关于骨盆测量的建议):21/35(60%)名同意的参与者接受了磁共振扫描。研究过程中未发生不良事件,所有参与者均可接受。19名患者提供了数据,其中7人(37%)因CPD而进行了剖腹产(CS),7人(37%)进行了辅助阴道分娩(AVB),5人(26%)进行了自然阴道分娩(SVD)。两名选择 CS 的患者未纳入分析。与顺产/剖宫产相比,自然阴道分娩组的骨盆测量值,尤其是解剖共轭(入口)、横径(中腔)和出口处的前胸径更大。放射科医生之间的磁共振扫描测量结果具有可比性:类内相关系数(ICC)范围为 0.68 至 0.95:这项可行性研究表明,为回答 "MR 骨盆测量法能否预测身材矮小女性的 CPD?研究对招募、磁共振扫描方案、报告、测量的可靠性等方面进行了评估,结果表明可以进行试验。与自然分娩/SVD 的妇女相比,需要干预的妇女的骨盆测量值有变小的趋势。如果有全面试验的证据,这将对身材矮小妇女的管理、临床实践和安全性产生重大影响:要评估磁共振骨盆测量是否能预测身材矮小女性的 CPD,进行大规模试验是可行的,也是可以接受的。尽管患者人数较少,但与自然阴道分娩的女性相比,需要干预的女性骨盆测量值有变小的趋势。来自大型试验的证据有助于为临床实践提供依据,并为有 CPD 风险的妇女提供信息和选择。
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A feasibility study of magnetic resonance pelvimetry in women of short stature to identify the risk of cephalo-pelvic disproportion

Objective

To conduct a feasibility study to assess if MR Pelvimetry can be undertaken in short stature primigravidae, with a view to a main study to answer the question ‘can MR pelvimetry be used to predict cephalo-pelvic disproportion (CPD) in women of short stature?’.

Study Design

This was a prospective single arm feasibility study. In the first phase, patient and public involvement was undertaken to assess acceptability of the study. In the second phase, primiparous women of ≤ 160 cm in height were selected from antenatal clinics. Obstetricians and midwives were asked to inform all eligible women about the study. Patients were approached in the third trimester and written information about the study provided. If the patient agreed to participate, they were invited for consent. MR scans were performed from 36 weeks gestation. Patients and their obstetricians were not informed of the results of the MR until after delivery (in view of NICE and WHO recommendations on pelvimetry).

Results

MR scans were performed on 21/35 (60%) participants who consented. The study was conducted without adverse events and was acceptable to all participants. Data were available from 19 patients; 7 (37%) of whom had caesarean section (CS) due to CPD, 7 (37%) had assisted vaginal birth (AVB), while 5 (26%) had spontaneous vaginal births (SVD). Two patients who had an elective CS were not included in the analysis. The pelvic measurements especially anatomical conjugate (inlet), transverse diameter (mid cavity) and anteroposterior diameter at the outlet were larger in the SVD group in comparison to in-labour CS /AVB. Interobserver MR scan measurements were comparable between radiologists: intraclass correlation coefficient (ICC) range 0.68 to 0.95.

Conclusion

This feasibility study suggests that conducting a full study to answer the research question ‘can MR pelvimetry predict CPD in women of short stature? would be feasible and acceptable to patients. The recruitment, MR scan protocol, reporting, reliability of measures were all assessed and found acceptable for a trial. A trend was observed for smaller pelvic measurements in women who needed intervention compared with those who had a natural birth/SVD. With evidence from a full trial, this could have major implications for the management of short stature women, in terms of clinical practice and safety.

Key messages

A large trial would be feasible and acceptable to assess whether MR pelvimetry can predict CPD in women of short stature. Despite the small number of patients, a trend was observed for smaller pelvic measurements in women who needed intervention compared to those who had spontaneous vaginal birth. Evidence from a large trial could help inform clinical practice, and provide information and choice for women at risk of CPD.
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来源期刊
CiteScore
4.60
自引率
3.80%
发文量
898
审稿时长
8.3 weeks
期刊介绍: The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.
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