Philomina Panin Edjah , Mao-Fang Lu , Wei-Chen Chen , Jun Wu , Yu-Ting Zhong , Mu Li , Qi Chen , Kong-Kai Zhu , Rui-Ying Yuan , Wei-Xin Tao , Ke-Jia Wu , You-Sheng Cai
{"title":"Aculeaquamides B 和 C，两种新的对位喹酰胺，来自黑曲霉 WHUF0198 和青霉 DM27 的共培养。","authors":"Philomina Panin Edjah , Mao-Fang Lu , Wei-Chen Chen , Jun Wu , Yu-Ting Zhong , Mu Li , Qi Chen , Kong-Kai Zhu , Rui-Ying Yuan , Wei-Xin Tao , Ke-Jia Wu , You-Sheng Cai","doi":"10.1016/j.fitote.2024.106251","DOIUrl":null,"url":null,"abstract":"<div><div>Two new paraherquamides (PHQs) namely aculeaquamides B and C (<strong>1</strong> and <strong>2</strong>), along with four known PHQs (<strong>3</strong>–<strong>6</strong>), were isolated from the co-culture of marine fungus <em>Aspergillus aculeatinus</em> WHUF0198 and mangrove-associated fungus <em>Penicillium</em> sp. DM27. Compound <strong>1</strong> represents the first PHQ derivative featuring an uncommon 7/6/5/5/6/5 hexacyclic system. The structures of the isolated compounds were elucidated based on exhaustive NMR spectroscopy measurement and HRESIMS data. The absolute configurations of new compounds were determined by TDDFT-ECD calculations. Compound <strong>3</strong> demonstrated suppression of AngII-induced cardiac hypertrophy while exhibiting relatively low cardiomyocyte toxicity.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aculeaquamides B and C, two new paraherquamides from the co-culture of Aspergillus aculeatinus WHUF0198 and Penicillium sp. DM27\",\"authors\":\"Philomina Panin Edjah , Mao-Fang Lu , Wei-Chen Chen , Jun Wu , Yu-Ting Zhong , Mu Li , Qi Chen , Kong-Kai Zhu , Rui-Ying Yuan , Wei-Xin Tao , Ke-Jia Wu , You-Sheng Cai\",\"doi\":\"10.1016/j.fitote.2024.106251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Two new paraherquamides (PHQs) namely aculeaquamides B and C (<strong>1</strong> and <strong>2</strong>), along with four known PHQs (<strong>3</strong>–<strong>6</strong>), were isolated from the co-culture of marine fungus <em>Aspergillus aculeatinus</em> WHUF0198 and mangrove-associated fungus <em>Penicillium</em> sp. DM27. Compound <strong>1</strong> represents the first PHQ derivative featuring an uncommon 7/6/5/5/6/5 hexacyclic system. The structures of the isolated compounds were elucidated based on exhaustive NMR spectroscopy measurement and HRESIMS data. The absolute configurations of new compounds were determined by TDDFT-ECD calculations. Compound <strong>3</strong> demonstrated suppression of AngII-induced cardiac hypertrophy while exhibiting relatively low cardiomyocyte toxicity.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24004349\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004349","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Aculeaquamides B and C, two new paraherquamides from the co-culture of Aspergillus aculeatinus WHUF0198 and Penicillium sp. DM27
Two new paraherquamides (PHQs) namely aculeaquamides B and C (1 and 2), along with four known PHQs (3–6), were isolated from the co-culture of marine fungus Aspergillus aculeatinus WHUF0198 and mangrove-associated fungus Penicillium sp. DM27. Compound 1 represents the first PHQ derivative featuring an uncommon 7/6/5/5/6/5 hexacyclic system. The structures of the isolated compounds were elucidated based on exhaustive NMR spectroscopy measurement and HRESIMS data. The absolute configurations of new compounds were determined by TDDFT-ECD calculations. Compound 3 demonstrated suppression of AngII-induced cardiac hypertrophy while exhibiting relatively low cardiomyocyte toxicity.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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