Hermansones A 和 B：欧洲结壳真菌 Hermanssonia centrifuga 中具有生物活性的萘甲萘嗪同系物。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-10-16 DOI:10.1016/j.fitote.2024.106261

Winnie Chemutai Sum , Sherif S. Ebada , Jackson M. Muema , Harald Kellner , Attila Mándi , Tibor Kurtán , Marc Stadler

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引用次数: 0

摘要

研究人员从木材腐朽基枝菌 Hermanssonia centrifuga 中分离出了两种以前未曾描述过的萘噻嗪类化合物，分别命名为 hermansones A (1) 和 B (2)。该研究首次报道了来自该物种的天然产物。通过核磁共振光谱和质谱分析，阐明了次级代谢产物的结构。通过 TDDFT-ECD 计算，阐明了化合物 1 的绝对构型。Hermansone B（2）对基孔肯雅病毒有中等程度的抑制作用，其 IC50 值为 55.97 μM，但不会引起明显的细胞毒性。

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Hermansones A and B: Bioactive naphthazarin congeners from the European crust fungus Hermanssonia centrifuga

Two previously undescribed naphthazarins named hermansones A (1) and B (2), were isolated from the wood-decaying basidiomycete Hermanssonia centrifuga. The study presents the first report of natural products from the species. The structures of the secondary metabolites were elucidated through NMR spectroscopy and mass spectrometry. The absolute configuration of compound 1 was elucidated using TDDFT-ECD calculations. Hermansone B (2) demonstrated moderate inhibitory effects against Chikungunya virus at IC₅₀ of 55.97 μM, without inducing notable cytotoxicity.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.