从宁波黄芩根中提取的六种新的酚苷。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-10-16 DOI:10.1016/j.fitote.2024.106258

You-Chen Li , Peng Liu , Ying-Ying Su , Chang Xu , Meng Sun , Wei Zhang , Bin Liu

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引用次数: 0

摘要

从宁波黄芩的根中分离出了六种新的酚苷类化合物（1-6）和十三种已知化合物（7-19）。通过对理化性质和光谱数据（一维核磁共振、二维核磁共振和 HR-ESI-MS）的综合分析，确定了这些化合物的结构。通过测定所有化合物抑制 RAW 264.7 巨噬细胞中脂多糖（LPS）诱导的 NO 生成的能力，评估了它们的抗炎潜力。此外，还评估了所有化合物对 HepG2、4 T1 和 A549 细胞系的细胞毒性。

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Six new phenolic glycosides from the roots of Scrophularia ningpoensis

Six new phenolic glycosides (1–6) and thirteen known compounds (7–19) were isolated from the roots of Scrophularia ningpoensis. Their structures were determined through comprehensive analyses of the physicochemical properties and spectroscopic data (1D NMR, 2D NMR, and HR-ESI-MS). The anti-inflammatory potential of all compounds was evaluated by determining their ability to inhibit lipopolysaccharide (LPS) induced NO production in RAW 264.7 macrophage cells. In addition, the cytotoxicity of all compounds on HepG2, 4T1 and A549 cell lines was also evaluated.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.