具有抗寨卡病毒活性的六种来自 Dodonaea viscosa 的新前基黄酮类化合物。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-10-18 DOI:10.1016/j.fitote.2024.106264

Wen-Hui Pang , Bin-Bao Wang , Yong-Xiang Huang , Xue-Mei Zhou , Xue-Wen Wu , Muhammad Aurang Zeb , Rui-Han Zhang , Ning Huang , Xiao-Li Li , Chang-Bo Zheng , Wei-Lie Xiao

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引用次数: 0

摘要

从 Dodonaea viscosa (L.) Jacq 分离出六种新的前烯基黄酮类化合物，命名为 visconaeas A-F（1-6），以及十一种已知的异戊烯基黄酮类化合物（7-17）。通过综合光谱分析和量子化学计算，确定了分离出的化合物的结构。对这些化合物进行了抗寨卡病毒和细胞毒性活性测试。结果表明，化合物 4 显示出较低的细胞毒性和较强的抗寨卡病毒潜力，EC50 为 16.34 μM。

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Six new prenylated flavonoids from Dodonaea viscosa with anti-Zika virus activity

Six new prenylated flavonoids, named visconaeas A-F (1–6), and eleven known isopentenyl flavonoids (7–17) were isolated from Dodonaea viscosa (L.) Jacq. The structures of the separated compounds were determined through comprehensive spectral analysis and quantum chemical calculations. These compounds were tested for their anti-Zika virus and cytotoxicity activities. The results indicated that compound 4 showed low cytotoxicity and strong anti-Zika virus potential with EC₅₀ 16.34 μM.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.